1.14.12.22: carbazole 1,9a-dioxygenase
This is an abbreviated version!
For detailed information about carbazole 1,9a-dioxygenase, go to the full flat file.
Word Map on EC 1.14.12.22
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1.14.12.22
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ferredoxin
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rieske
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resinovorans
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carac
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carbazole-degradation
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dibenzo-p-dioxins
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dibenzofurans
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fluorene
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aromaticivorans
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nocardioides
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dianhydride
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dibenzothiophene
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polyimide
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janthinobacterium
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stipes
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degradation
- 1.14.12.22
- ferredoxin
-
rieske
- resinovorans
- carac
-
carbazole-degradation
- dibenzo-p-dioxins
- dibenzofurans
- fluorene
- aromaticivorans
-
nocardioides
-
dianhydride
- dibenzothiophene
-
polyimide
- janthinobacterium
-
stipes
- degradation
Reaction
Synonyms
CarAa, CarAc, carbazole dioxygenase, CARDO, CARDO-F, CARDO-R
ECTree
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Reaction
Reaction on EC 1.14.12.22 - carbazole 1,9a-dioxygenase
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9H-carbazole + NAD(P)H + H+ + O2 = 2'-aminobiphenyl-2,3-diol + NAD(P)+
catalytic mechanism is as follows: When the Rieske cluster is reduced, substrate binding induces several conformational changes that create room for oxygen binding. Dioxygen bound in a side-on fashion onto nonheme iron is activated by reduction to the peroxo state [Fe(III)-(hydro)peroxo]. This state may react directly with the bound substrate, or O-O bond cleavage may occur to generate Fe(V)-oxo-hydroxo species prior to the reaction. After producing a cisdihydrodiol, the product is released by reducing the nonheme iron