1.14.12.25: p-cumate 2,3-dioxygenase

This is an abbreviated version!
For detailed information about p-cumate 2,3-dioxygenase, go to the full flat file.

Reaction

p-cumate
+
NADH
+
H+
+
O2
=
(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate
+
NAD+

Synonyms

CmtAa, CmtAb, CmtAc, CmtAd, p-cumate dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.25 p-cumate 2,3-dioxygenase

Systematic Name

Systematic Name on EC 1.14.12.25 - p-cumate 2,3-dioxygenase

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SYSTEMATIC NAME
IUBMB Comments
4-isopropylbenzoate:oxygen 2,3-oxidoreductase
The enzyme, characterized from several Pseudomonas strains, is involved in the degradation of p-cymene and p-cumate. It comprises four components: a ferredoxin, a ferredoxin reductase, and two subunits of a catalytic component. The enzyme can also act on indole, transforming it to the water-insoluble blue dye indigo.