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1.14.13.101: senecionine N-oxygenase

This is an abbreviated version!
For detailed information about senecionine N-oxygenase, go to the full flat file.

Reaction

senecionine
+
NADPH
+
H+
+
O2
=
senecionine N-oxide
+
NADP+
+
H2O

Synonyms

flavin-dependent monooxygenase, fmoa, GgPNO, oxygenase, senecionine N-, PA N-oxygenase, PNO, pyrrolizidine alkaloid N-oxygenase, senecionine monooxygenase (N-oxide-forming), senecionine N-oxygenase, SNO, TjSNO, ZvFMOa, ZvPNO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.101 senecionine N-oxygenase

General Information

General Information on EC 1.14.13.101 - senecionine N-oxygenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
during evolution, different insect lineages have developed specialized FMOs, pyrrolizidine alkaloid N-oxygenases (PNOs), as a counterstrategy to cope with pyrrolizidine alkaloids (PAs), which are toxic compounds that are produced by certain angiosperm species as part of their chemical defence against herbivores. PAs are produced by plants in their nontoxic polar N-oxide form. Isonzyme ZvPNO belongs to the flavin-dependent monooxygenases (FMOs), it is a member of class B (of six different FMO subclasses, A-F) within the family of flavin-dependent monooxygenases that originates from a more highly developed organism than yeast. Despite the differences in sequence between family members, their overall structure is very similar. PA N-oxygenases are the only functionally characterized FMOs found to date in insects
physiological function
additional information