1.14.13.101: senecionine N-oxygenase

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For detailed information about senecionine N-oxygenase, go to the full flat file.

Reaction

Synonyms

flavin-dependent monooxygenase, fmoa, GgPNO, oxygenase, senecionine N-, PA N-oxygenase, PNO, pyrrolizidine alkaloid N-oxygenase, senecionine monooxygenase (N-oxide-forming), senecionine N-oxygenase, SNO, TjSNO, ZvFMOa, ZvPNO

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.101 senecionine N-oxygenase

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Results	in table
3	Activating Compound
6	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
10	Cofactor
2	Crystallization (Commentary)
4	General Information
1	Inhibitors
5	kcat/KM [mM/s]
15	KM Value [mM]
3	Localization
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
16	Organism
3	Pathway
5	pH Optimum
1	pI Value
7	Protein Variants
5	Purification (Commentary)
1	Reaction
9	Reaction Type
15	Reference
13	Source Tissue
2	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
4	Subunits
18	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.13.101 - senecionine N-oxygenase

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senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming)

A flavoprotein. NADH cannot replace NADPH. While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates [1]. Senecionine N-oxide is used by insects as a chemical defense: senecionine N-oxide is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P-450 oxidase when absorbed by insectivores.