1.14.13.113: FAD-dependent urate hydroxylase
This is an abbreviated version!
For detailed information about FAD-dependent urate hydroxylase, go to the full flat file.
Reaction
Synonyms
FAD-dependent urate oxidase, flavin adenine dinucleotide-dependent urate oxidase, HpxO, HpxO enzyme, HpyO, urate hydroxylase, XCC0279
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Substrates Products
Substrates Products on EC 1.14.13.113 - FAD-dependent urate hydroxylase
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REACTION DIAGRAM
urate + NADPH + H+ + O2
5-hydroxyisourate + NADP+ + H2O
the enzyme is slightly more efficient (about 2.6times) with NADPH than NADH
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additional information
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urate oxidase can catalyze the slow conversion of NADPH to NADP+ in the absence of urate
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5-hydroxyisourate + NAD+ + H2O
part of the purine catabolic pathway
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urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
part of the purine catabolic pathway
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urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
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part of the purine catabolic pathway
unstable in aqueous buffer, hydrolyzing spontaneously to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
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urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
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urate hydroxylase shows selectivity (V/K ratio of 10) for NADH over NADPH
unstable in aqueous buffer, hydrolyzing spontaneously to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
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urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
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-
-
?
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
the enzyme is slightly more efficient (about 2.6times) with NADPH than NADH
-
-
?