1.14.13.127: 3-(3-hydroxyphenyl)propanoate hydroxylase

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For detailed information about 3-(3-hydroxyphenyl)propanoate hydroxylase, go to the full flat file.

Reaction

(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate

Synonyms

3-(3-hydroxyphenyl)propionate hydroxylase, 3HPP 2-hydroxylase, 3HPP hydroxylase, MhpA, MhpAK-12

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase

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Results	in table
2172	AA Sequence
1	Cloned(Commentary)
9	Cofactor
1	Expression
8	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
13	Organism
7	Pathway
1	pH Optimum
2	Protein Variants
1	Purification (Commentary)
2	Reaction
11	Reference
2	Specific Activity [micromol/min/mg]
13	Substrates and Products (Substrate)
2	Subunits
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Reaction

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Reaction on EC 1.14.13.127 - 3-(3-hydroxyphenyl)propanoate hydroxylase

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(2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+

(2)

3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+

the His-Cys catalytic diad in free papain is fully protonated, -NH(+)/-SH. The experimental pKa of 8.62 for His159 imidazole in free papain is assigned to the -NH(+)/-SH and -N/-SH equilibrium