1.14.13.148: trimethylamine monooxygenase
This is an abbreviated version!
For detailed information about trimethylamine monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.148
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1.14.13.148
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1.14.13.8
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flavin-containing
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trimethylamine-n-oxide
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fad-containing
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trimethylaminuria
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methimazole
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n-oxygenation
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dimethylaniline
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s-oxidation
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n-octylamine
- 1.14.13.148
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1.14.13.8
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flavin-containing
- trimethylamine-n-oxide
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fad-containing
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trimethylaminuria
- methimazole
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n-oxygenation
- dimethylaniline
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s-oxidation
- n-octylamine
Reaction
Synonyms
dimethyl sulfoxide/trimethylamine N-oxide reductase, EC 1.14.13.8, FAD-containing monooxygenase, flavin containing monooxygenase 3, flavin monooxygenase 3, flavin-containing monooxygenase, flavin-containing monooxygenase 3, FMO, FMO3, FMO4, PB7211, TMA monooxygenase, TMA N-oxygenase, TMM
ECTree
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Activating Compound
Activating Compound on EC 1.14.13.148 - trimethylamine monooxygenase
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chlorpromazine
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the activity of the native enzyme is increased at 0.001-0.2 mM of chlorpromazine. Greatest activation is 85% when methimazole and chlorpromazine concentrations are 2 mM and 0.1 mM, respectively
imipramine
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the activity of the native enzyme is increased at 0.05-0.75 mM of imipramine
O2
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when the oxygen in the enzyme assay mixture is replaced with 100% nitrogen, there is no formation of N,N,N-trimethylamine N-oxide, showing that the enzyme is oxygen-dependent
n-octylamine has no effect on isoform FMO3
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additional information
n-octylamine has no effect on isoform FMO3
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