1.14.13.158: amorpha-4,11-diene 12-monooxygenase

This is an abbreviated version, for detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

Reaction

amorpha-4,11-diene
+ 3 O2 + 3 NADPH + 3 H+ =
artemisinate
+ 3 NADP+ + 4 H2O

Synonyms

ALDH1, amorpha-4,11-diene C-12 oxidase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.158 amorpha-4,11-diene 12-monooxygenase

Reaction

Reaction on EC 1.14.13.158 - amorpha-4,11-diene 12-monooxygenase

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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ = artemisinate + 3 NADP+ + 4 H2O
show the reaction diagram
overall reaction
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amorpha-4,11-diene + O2 + NADPH + H+ = artemisinic alcohol + NADP+ + H2O
show the reaction diagram
(1a)
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artemisinic alcohol + O2 + NADPH + H+ = artemisinic aldehyde + NADP+ + 2 H2O
show the reaction diagram
(1b)
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artemisinic aldehyde + O2 + NADPH + H+ = artemisinate + NADP+ + H2O
show the reaction diagram
(1c)
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