1.14.13.158: amorpha-4,11-diene 12-monooxygenase

This is an abbreviated version, for detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

Reaction

amorpha-4,11-diene
+ 3 O2 + 3 NADPH + 3 H+ =
artemisinate
+ 3 NADP+ + 4 H2O

Synonyms

ALDH1, amorpha-4,11-diene C-12 oxidase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.158 amorpha-4,11-diene 12-monooxygenase

Reference

Reference on EC 1.14.13.158 - amorpha-4,11-diene 12-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Olsson, M.E.; Olofsson, L.M.; Lindahl, A.L.; Lundgren, A.; Brodelius, M.; Brodelius, P.E.
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L
Phytochemistry
70
1123-1128
2009
Artemisia annua
Manually annotated by BRENDA team
Alejos-Gonzalez, F.; Qu, G.; Zhou, L.L.; Saravitz, C.H.; Shurtleff, J.L.; Xie, D.Y.
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
Planta
234
685-697
2011
Artemisia annua
Manually annotated by BRENDA team
Teoh, K.; Polichuk, D.; Reed, D.; Covello, P.
Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua
Botany
87
635-642
2009
Artemisia annua, Artemisia annua (C5I9X1)
-
Manually annotated by BRENDA team
Teoh, K.H.; Polichuk, D.R.; Reed, D.W.; Nowak, G.; Covello, P.S.
Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin
FEBS Lett.
580
1411-1416
2006
Artemisia annua, Artemisia annua (Q1PS23)
Manually annotated by BRENDA team
Zhang, Y.; Nowak, G.; Reed, D.W.; Covello, P.S.
The production of artemisinin precursors in tobacco
Plant Biotechnol. J.
9
445-454
2011
Artemisia annua
Manually annotated by BRENDA team