1.14.13.158: amorpha-4,11-diene 12-monooxygenase

This is an abbreviated version, for detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

Reaction

amorpha-4,11-diene
+ 3 O2 + 3 NADPH + 3 H+ =
artemisinate
+ 3 NADP+ + 4 H2O

Synonyms

ALDH1, amorpha-4,11-diene C-12 oxidase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.158 amorpha-4,11-diene 12-monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.158 - amorpha-4,11-diene 12-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating)
A heme-thiolate protein (P-450). Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin.