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1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase

This is an abbreviated version!
For detailed information about 6-hydroxy-3-succinoylpyridine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.163

Reaction

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate
+ 2 NADH + 2 H+ +
O2
=
2,5-dihydroxypyridine
 +
succinate semialdehyde
 + 2 NAD+ +
H2O

Synonyms

6-hydroxy-3-succinoyl-pyridine 3-monooxygenase, 6-hydroxy-3-succinoylpyridine hydroxylase, AWN88_01205, Hsh, HSP 3-monooxygenase, HSP hydroxylase, HSP monooxygenase, hspA, hspB, HSPH, HSPHZZ, NADH-dependent HSP hydroxylase, NIC, nicotine hydroxylase, VppD, W7K_00670

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.163 6-hydroxy-3-succinoylpyridine 3-monooxygenase

Reference

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Reference on EC 1.14.13.163 - 6-hydroxy-3-succinoylpyridine 3-monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tang, H.; Wang, S.; Ma, L.; Meng, X.; Deng, Z.; Zhang, D.; Ma, C.; Xu, P.
A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16
Appl. Environ. Microbiol.
74
1567-1574
2008
Pseudomonas putida (B1N1A2), Pseudomonas putida S16 (B1N1A2), Pseudomonas putida S16
Manually annotated by BRENDA team
Wang, S.; Huang, H.; Xie, K.; Xu, P.
Identification of nicotine biotransformation intermediates by Agrobacterium tumefaciens strain S33 suggests a novel nicotine degradation pathway
Appl. Microbiol. Biotechnol.
95
1567-1578
2012
Agrobacterium tumefaciens, Agrobacterium tumefaciens S33
Manually annotated by BRENDA team
Tang, H.; Yao, Y.; Zhang, D.; Meng, X.; Wang, L.; Yu, H.; Ma, L.; Xu, P.
A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida
J. Biol. Chem.
286
39179-39187
2011
Pseudomonas putida (F8G0M4), Pseudomonas putida, Pseudomonas putida S16 (F8G0M4), Pseudomonas putida S16
Manually annotated by BRENDA team
Yu, H.; Tang, H.; Zhu, X.; Li, Y.; Xu, P.
Molecular mechanism of nicotine degradation by a newly isolated strain, Ochrobactrum sp. strain SJY1
Appl. Environ. Microbiol.
81
272-281
2015
Ochrobactrum sp. (A0A075XAG5)
Manually annotated by BRENDA team
Li, H.; Xie, K.; Yu, W.; Hu, L.; Huang, H.; Xie, H.; Wang, S.
Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33
Appl. Environ. Microbiol.
82
1745-1755
2016
Agrobacterium tumefaciens (W8E0Y0), Agrobacterium tumefaciens S33 (W8E0Y0)
Manually annotated by BRENDA team
Wei, T.; Zang, J.; Zheng, Y.; Tang, H.; Huang, S.; Mao, D.
Characterization of a novel nicotine hydroxylase from Pseudomonas sp. ZZ-5 that catalyzes the conversion of 6-hydroxy-3-succinoylpyridine into 2,5-dihydroxypyridine
Catalysts
7
272-281
2017
Pseudomonas sp. ZZ-5
Manually annotated by BRENDA team
Yu, H.; Hausinger, R.; Tang, H.; Xu, P.
Mechanism of the 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase flavoprotein from Pseudomonas putida S16
J. Biol. Chem.
289
29158-29170
2014
Pseudomonas putida, Pseudomonas putida S16
Manually annotated by BRENDA team
Li, H.; Xie, K.; Huang, H.; Wang, S.
6-hydroxy-3-succinoylpyridine hydroxylase catalyzes a central step of nicotine degradation in Agrobacterium tumefaciens S33
PLoS ONE
9
e103324
2014
Agrobacterium tumefaciens (W8E0Y0), Agrobacterium tumefaciens S33 (W8E0Y0), Agrobacterium tumefaciens S33
Manually annotated by BRENDA team
Dong, C.; Zheng, Y.; Tang, H.; Long, Z.; Li, J.; Zhang, Z.; Liu, S.; Mao, D.; Wei, T.
Highly efficient synthesis of 2,5-dihydroxypyridine using Pseudomonas sp. ZZ-5 nicotine hydroxylase immobilized on immobead 150
Catalysts
8
548
2018
Pseudomonas sp. ZZ-5
-
Manually annotated by BRENDA team
Wang, W.; Zhu, X.; Liu, X.; Wu, W.; Xu, P.; Tang, H.
Cloning and characterization the nicotine degradation enzymes 6-hydroxypseudooxynicotine amine oxidase and 6-hydroxy-3-succinoylpyridine hydroxylase in Pseudomonas geniculata N1
Int. Biodeter. Biodegrad.
142
83-90
2019
Stenotrophomonas geniculata (A0A0L8AFM7), Stenotrophomonas geniculata N1 (A0A0L8AFM7)
-
Manually annotated by BRENDA team