1.14.13.167: 4-nitrophenol 4-monooxygenase
This is an abbreviated version!
For detailed information about 4-nitrophenol 4-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.167
-
1.14.13.167
-
sumo
-
ubiquitin-conjugating
-
sumoylation
-
hydroxyquinol
-
sumo-conjugating
-
two-component
-
rhodococcus
-
ubiquitin-like
-
para-nitrophenol
-
hydroquinone
-
1,2-dioxygenase
- 1.14.13.167
-
sumo
-
ubiquitin-conjugating
-
sumoylation
- hydroxyquinol
-
sumo-conjugating
-
two-component
-
rhodococcus
-
ubiquitin-like
- para-nitrophenol
- hydroquinone
-
1,2-dioxygenase
Reaction
Synonyms
2C4NP 4-monooxygenase, 4-NP/4-NCA monooxygenase, NpcA, para-nitrophenol 4-monooxygenase, PdcA, PNP 4-monooxygenase, pnpA, PnpA1
ECTree
Advanced search results
General Information
General Information on EC 1.14.13.167 - 4-nitrophenol 4-monooxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
metabolism
physiological function
-
the npcA mutant strain SDA1 completely loses the ability to grow on 4-nitrophenol as the sole carbon source
malfunction
-
the npcA mutant strain SDA1 completely loses the ability to grow on 4-nitrophenol as the sole carbon source
-
-
the enzyme is involved in 3-methyl-4-nitrophenol degradation in Burkholderia sp. strain SJ98, phathway overview. Methyl-1,4-benzoquinone (MBQ) and methylhydroquinone (MHQ), rather than catechol proposed previously, are identified as the intermediates before ring cleavage during 3-methyl-4-nitrophenol degradation by Burkholderia sp. strain SJ98. By sequential catalysis assays, PnpCD, PnpE, and PnpF are likely involved in the further pathway of 3-methyl-4-nitrophenol catabolism
metabolism
-
the enzymes responsible for 4-nitrophenol catabolism are also likely to be involved in 2-chloro-4-nitrophenol degradation. Catabolism of 2-chloro-4-nitrophenol and of 4-nitrophenolshare the same gene cluster in strain SJ98
para-nitrophenol 4-monooxygenase gene pnpA plays an essential role in 4-nitrophenol mineralization in strain Pseudomonas putida strain WBC-3
physiological function
-
PnpA, a PNP 4-monooxygenase, is able to catalyze the monooxygenation of 2-chloro-4-nitrophenol to 2-chloro-1,4-benzoquinone. PnpB, a 1,4-benzoquinone reductase, has the ability to catalyze the reduction of 2-chloro-1,4-benzoquinone to chlorohydroquinone. Moreover, PnpB is also able to enhance PnpA activity in vitro in the conversion of 2-chloro-4-nitrophenol to 2-chloro-1,4-benzoquinone. Gene pnpA plays an essential role in the degradation of both 2-chloro-4-nitrophenol and 4-nitrophenol. Catabolism of 2-chloro-4-nitrophenol and of 4-nitrophenolshare the same gene cluster in strain SJ98
physiological function
-
PnpA, a PNP 4-monooxygenase, is able to catalyze the monooxygenation of 3-methyl-4-nitrophenol to 3-methyl-1,4-benzoquinone. PnpB, a 1,4-benzoquinone reductase, has the ability to catalyze the reduction of 3-methyl-1,4-benzoquinone to methylhydroquinone. Moreover, PnpB is also able to enhance PnpA activity in vitro in the conversion of 3-methyl-4-nitrophenol to 3-methyl-1,4-benzoquinone
physiological function
-
PnpA1, a PNP 4-monooxygenase, is able to catalyze the monooxygenation of 2-chloro-4-nitrophenol to 2-chloro-1,4-benzoquinone
physiological function
2-chloro-4-nitrophenol serves as a substrate for the 4-monooxygenase PnpA, but wild-type is unable to utilize 2-chloro-4-nitrophenol. Transcriptional regulator PnpR variant S6C drives the 4-nitrophenol-independent expression of PnpA and PnpB operons in an almost constitutive manner and allows higher levels of induction upon addition of inducers. When the pnpRS6C allele is introduced into a PnpR-deleted mutant, the corresponding strain acquires the ability to grow on 2-chloro-4-nitrophenol but is still able to utilize 4-nitrophenol for growth
physiological function
Rhodococcus opacus RKJ300
-
PnpA1, a PNP 4-monooxygenase, is able to catalyze the monooxygenation of 2-chloro-4-nitrophenol to 2-chloro-1,4-benzoquinone
-