1.14.13.168: indole-3-pyruvate monooxygenase
This is an abbreviated version!
For detailed information about indole-3-pyruvate monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.168
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1.14.13.168
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auxin
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iaa
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indole-3-acetic
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one-hybrid
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high-auxin
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gynoecium
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tryptophan-dependent
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auxin-response
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auxin-related
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dark-induced
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dr5::gus
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parthenocarpy
- 1.14.13.168
- auxin
- iaa
-
indole-3-acetic
-
one-hybrid
-
high-auxin
- gynoecium
-
tryptophan-dependent
-
auxin-response
-
auxin-related
-
dark-induced
-
dr5::gus
-
parthenocarpy
Reaction
Synonyms
At5g25620, Cc06_g09670, flavin-containing monooxygenase YUC, spi1, YUC, YUC1, YUC10, YUC10.3, YUC11, YUC2, YUC3, YUC4, YUC5, YUC6, YUC7, YUC8, YUC9, YUCCA, YUCCA1, YUCCA2, YUCCA4, YUCCA6
ECTree
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Inhibitors
Inhibitors on EC 1.14.13.168 - indole-3-pyruvate monooxygenase
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2-chlorophenylboronic acid
moderate inhibition of enzyme activity and primary root elongation. Probably unspecific inhibition
3,5-dibromophenylboronic acid
probably unspecific inhibition, inhibits root hair formation in wild-type Arabidopsis thaliana seedlings
3,5-dichlorophenylboronic acid
probably unspecific inhibition, inhibits root hair formation in wild-type Arabidopsis thaliana seedlings
3-chlorophenylboronic acid
probably unspecific inhibition, strongly inhibits root hair formation in wild-type Arabidopsis thaliana seedlings
4-biphenylboronic acid
BBo, competitive, inhibits the activity of recombinant YUC in vitro, reduces endogenous indole-3-acetic acid content, and strongly inhibits primary root elongation and lateral root formation in wild-type Arabidopsis thaliana seedlings
4-chlorophenylboronic acid
probably unspecific inhibition, strongly inhibits root hair formation in wild-type Arabidopsis thaliana seedlings
4-methyl-4-biphenylboronic acid
weak inhibition of enzyme activity, but strong inhibition of primary root elongation
4-phenoxyphenylboronic acid
PPBo, competitive, inhibits the activity of recombinant YUC in vitro, reduces endogenous indole-3-acetic acid content, and strongly inhibits primary root elongation and lateral root formation in wild-type Arabidopsis thaliana seedlings. The compound does not interfere with the auxin response of auxin-marker genes when it was co-treated with indole acetic acid, suggesting that PPBo is not an inhibitor of auxin sensing or signaling
phenethylboronic acid
moderate inhibition of enzyme activity and primary root elongation
phenylboronic acid
PBo, inhibition of enzyme activity, but not of primary root elongation
ponalrestat
ponalrestat suppresses the native auxin signal and protects a GST-YUC2 fusion protein from Pronase degradation. Ponalrestat has an inhibitory effect on YUC2 protein, fits into the active site pocket of YUC2 and may act as a substrate antagonist. Treatment suppresses root hair formation and interrupts root gravitropic growth; ponalrestat suppresses the native auxin signal. Treatment suppresses root hair formation and interrupts root gravitropic growth
yucasin
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in isoform YUC2, yucasin competes for the same site as indole pyruvic acid, blocking indole acetic acid production
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additional information
FAD and boronic acid is not the main reason for inhibition of enzyme activity by boronic acid derivatives. Poor inhibition by 2,6-dichlorophenylboronic acid
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