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1.14.13.178: methylxanthine N1-demethylase

This is an abbreviated version!
For detailed information about methylxanthine N1-demethylase, go to the full flat file.

Reaction

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Caffeine
+
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O2
 +
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NAD(P)H
 +
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H+
=
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Theobromine
 +
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NAD(P)+
 +
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H2O
 +
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formaldehyde

Synonyms

ndmA, P450-d

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                EC 1.14.13.1781.14.13.178 methylxanthine N1-demethylase

Natural Substrates Products

Natural Substrates Products on EC 1.14.13.178 - methylxanthine N1-demethylase

for references in articles please use BRENDA:EC1.14.13.178

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
caffeine + O2 + NAD(P)H + H+
theobromine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
paraxanthine + O2 + NAD(P)H + H+
7-methylxanthine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
theophylline + O2 + NAD(P)H + H+
3-methylxanthine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
Substrates: the enzyme forms part of the degradation pathway of methylxanthines. The activity of the enzyme is dependent on electron transfer from NADH via a redox-center-dense Rieske reductase, NdmD
Products: -
?
theophylline + O2 + NADPH + H+
3-methylxanthine + NADP+ + H2O + formaldehyde
show the reaction diagram
-
Substrates: i.e. 1,3-dimethylxanthine
Products: -
?