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1.14.13.179: methylxanthine N3-demethylase

This is an abbreviated version!
For detailed information about methylxanthine N3-demethylase, go to the full flat file.

Reaction

3-Methylxanthine
+
O2
+
NAD(P)H
+
H+
=
xanthine
+
NAD(P)+
+
H2O
+
formaldehyde

Synonyms

ndmB

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.179 methylxanthine N3-demethylase

Systematic Name

Systematic Name on EC 1.14.13.179 - methylxanthine N3-demethylase

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SYSTEMATIC NAME
IUBMB Comments
theobromine:oxygen oxidoreductase (N3-demethylating)
A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, methylxanthine N1-demethylase, and has higher activity with NADH than with NADPH [1]. Also demethylates caffeine and theophylline with lower efficiency. Forms part of the degradation pathway of methylxanthines.