1.14.13.181: 13-deoxydaunorubicin hydroxylase

This is an abbreviated version!
For detailed information about 13-deoxydaunorubicin hydroxylase, go to the full flat file.

Reaction

Synonyms

CYP109A2, DoxA, DoxA monooxygenase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.181 13-deoxydaunorubicin hydroxylase

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Results	in table
5	AA Sequence
3	Cloned(Commentary)
6	Cofactor
6	General Information
6	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
4	KM Value [mM]
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
10	Organism
6	Pathway
1	pH Optimum
2	Purification (Commentary)
2	Reaction
9	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
25	Substrates and Products (Substrate)
5	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

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Reference on EC 1.14.13.181 - 13-deoxydaunorubicin hydroxylase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

722492

Dickens, M.L.; Strohl, W.R.

Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24

J. Bacteriol.

178

3389-3395

1996

Streptomyces sp. (Q59971)

8655530

brenda

722495

Dickens, M.L.; Priestley, N.D.; Strohl, W.R.

In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA

J. Bacteriol.

179

2641-2650

1997

Streptomyces sp. (Q59971)

9098063

brenda

722500

Walczak, R.J.; Dickens, M.L.; Priestley, N.D.; Strohl, W.R.

Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesis

J. Bacteriol.

181

298-304

1999

Streptomyces sp. (Q59971)

9864343

brenda

722501

Lomovskaya, N.; Otten, S.L.; Doi-Katayama, Y.; Fonstein, L.; Liu, X.C.; Takatsu, T.; Inventi-Solari, A.; Filippini, S.; Torti, F.; Colombo, A.L.; Hutchinson, C.R.

Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene

J. Bacteriol.

181

305-318

1999

Streptomyces peucetius (Q9ZAU3), Streptomyces peucetius ATCC 29050 (Q9ZAU3)

9864344

brenda

722882

Vetrive,l K.S.; Dharmalingam, K.

Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis

J. Genet.

80

31-38

2001

Streptomyces peucetius

11910122

brenda

744164

Rimal, H.; Lee, S.; Lee, J.; Oh, T.

Understanding of real alternative redox partner of Streptomyces peucetius DoxA Prediction and validation using in silico and in vitro analyses

Arch. Biochem. Biophys.

585

64-74

2015

Streptomyces peucetius, Streptomyces peucetius ATCC 27952

26334717

brenda

765231

Rimal, H.; Yu, S.C.; Lee, J.H.; Tokutaro, Y.; Oh, T.J.

Hydroxylation of resveratrol with DoxA in vitro an enzyme with the potential for the bioconversion of a bioactive stilbene

J. Microbiol. Biotechnol.

28

561-565

2018

Streptomyces peucetius (Q9ZAU3)

29385664

brenda

Entries 1 - 20 of 7

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