1.14.13.2: 4-hydroxybenzoate 3-monooxygenase

This is an abbreviated version!
For detailed information about 4-hydroxybenzoate 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.2

Reaction

4-hydroxybenzoate
+
NADPH
+
H+
+
O2
=
3,4-dihydroxybenzoate
+
NADP+
+
H2O

Synonyms

4-HBA 3-hydroxylase, 4-HBA 3-monooxygenase, 4-HBA-3-hydroxylase, 4-HBMO, 4-hydroxybenzoate 3-hydroxylase, 4-hydroxybenzoate 3-monooxygenase, 4-hydroxybenzoate hydroxylase, 4-hydroxybenzoate monooxygenase, 4-hydroxybenzoic hydroxylase, 4HBA 3-hydroxylase, BxeA2040, HBH, m-hydroxybenzoate hydroxylase, MobA, ncgl1032, oxygenase, 4-hydroxybenzoate 3-mono-, p-hydroxybenzoate hydroxylase, p-hydroxybenzoate-3-hydroxylase, p-hydroxybenzoic acid hydrolase, p-hydroxybenzoic acid hydroxylase, p-hydroxybenzoic hydroxylase, para-hydroxybenzoate hydroxylase, PHBAD, PHBH, PHBHase, PobA, pobACg, POHBase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.2 4-hydroxybenzoate 3-monooxygenase

Substrates Products

Substrates Products on EC 1.14.13.2 - 4-hydroxybenzoate 3-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-dihydroxybenzoate + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
2,4-dihydroxybenzoate + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
2,4-dihydroxybenzoate + NADPH + O2
2,3,4-trihydroxybenzoate + 2,4,5-trihydroxybenzoate + NADP+ + H2O
show the reaction diagram
2,5-dihydroxybenzoate + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
2-chloro-4-hydroxybenzoate + NADH + O2
?
show the reaction diagram
2-fluoro-4-hydroxybenzoate + NADH + O2
?
show the reaction diagram
3,4-dihydroxybenzoate + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
3,4-dihydroxybenzoic acid + NADPH + H+ + O2
gallic acid + NADP+ + H2O
show the reaction diagram
-
weak activity
-
-
?
3,5-dihydroxybenzoate + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
3-bromo-4-hydroxybenzoate + NADPH + O2
?
show the reaction diagram
-
3.2% of the activity with 4-hydroxybenzoate
-
-
?
3-Chloro-4-hydroxybenzoate + NADPH + O2
?
show the reaction diagram
-
6.5% of the activity with 4-hydroxybenzoate
-
-
?
3-chlorophenol + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
?
3-Fluoro-4-hydroxybenzoate + NADPH + O2
?
show the reaction diagram
-
about 1% of the activity with 4-hydroxybenzoate
-
-
?
3-hydroxyanthranilate + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
?
4-aminobenzoate + NADPH + O2
?
show the reaction diagram
-
about 1% of the activity with 4-hydroxybenzoate
-
-
?
4-chlorophenol + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
?
4-chlororesorcinol + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
?
4-hydroxybenzoate + NADH + O2
protocatechuate + NAD+ + H2O
show the reaction diagram
4-hydroxybenzoate + NADPH + ferricyanide
protocatechuate + NADP+ + ferrocyanide
show the reaction diagram
-
-
-
?
4-hydroxybenzoate + NADPH + H+ + O2
protocatechuate + NADP+ + H2O
show the reaction diagram
4-hydroxybenzoate + NADPH + O2
?
show the reaction diagram
4-hydroxybenzoate + NADPH + O2
protocatechuate + NADP+ + H2O
show the reaction diagram
4-mercaptobenzoate + NADPH + O2
4,4'-dithiobisbenzoate + ?
show the reaction diagram
4-nitrophenol + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
?
4-toluate + NADPH + O2
?
show the reaction diagram
-
0.29% of the activity with 4-hydroxybenzoate
-
-
?
benzene sulfonate + NADPH + O2
?
show the reaction diagram
-
0.34% of the activity with 4-hydroxybenzoate
-
-
?
hydroquinone + NADP+ + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
?
m-hydroxybenzoate + NADPH + O2
protocatechuate + NADP+ + H2O
show the reaction diagram
-
-
-
?
p-hydroxybenzoate + NADPH + O2
? + NADP+ + H2O
show the reaction diagram
is transformed to a lesser extent than m-hydroxybenzoate
-
-
?
additional information
?
-