1.14.13.211: rifampicin monooxygenase

This is an abbreviated version!
For detailed information about rifampicin monooxygenase, go to the full flat file.

Reaction

Synonyms

RIF-O, rifampicin monooxygenase, RifMO, rox

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.211 rifampicin monooxygenase

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Results	in table
2	AA Sequence
3	Cloned(Commentary)
4	Cofactor
2	Crystallization (Commentary)
6	General Information
4	Natural Substrates/ Products (Substrates)
16	Organism
1	pH Optimum
2	Protein Variants
1	Reaction
13	Reference
14	Substrates and Products (Substrate)
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Reference on EC 1.14.13.211 - rifampicin monooxygenase

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734035

Hoshino, Y.;, Fujii, S., Shinonaga, H.; Arai, K.; Saito, F.; Fukai, T.; Satoh, H.; Miyazaki, Y.; Ishikawa, J.

Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance

J. Antibiot.

23-28

2010

Nocardia farcinica, Nocardia farcinica IFM 10152

19942945

735440

Andersen, S.; Quan, S.; Gowan, B.; Dabbs, E.

Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic

Antimicrob. Agents Chemother.

218-221

1997

Rhodococcus equi (P95598), Rhodococcus equi ATCC 14887 (P95598)

8980786

738694

Liu, L.K.; Abdelwahab, H.; Martin Del Campo, J.S.; Mehra-Chaudhary, R.; Sobrado, P.; Tanner, J.J.

The structure of the antibiotic deactivating, N-hydroxylating rifampicin monooxygenase

J. Biol. Chem.

291

21553-21562

2016

Nocardia farcinica (Q5YTV5), Nocardia farcinica, Nocardia farcinica IFM 10152 (Q5YTV5)

27557658

764146

Liu, L.K.; Dai, Y.; Abdelwahab, H.; Sobrado, P.; Tanner, J.J.

Structural evidence for rifampicin monooxygenase inactivating rifampicin by cleaving its ansa-bridge

Biochemistry

2065-2068

2018

Nocardia farcinica (Q5YTV5), Nocardia farcinica IFM 10152 (Q5YTV5)

29578336

764739

Zheng, X.; Liu, X.; Peng, S.; Zhou, Q.; Xu, B.; Yuan, H.; Tang, G.

Characterization of the rifamycin-degrading monooxygenase from rifamycin producers implicating its involvement in saliniketal biosynthesis

Front. Microbiol.

971

2020

Amycolatopsis mediterranei, Salinispora arenicola, Nocardioides dokdonensis, Streptomyces sp. TP-A0356, Micromonospora sp. TP-A0468

32582048