1.14.13.225: F-actin monooxygenase
This is an abbreviated version!
For detailed information about F-actin monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.225
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1.14.13.225
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plexins
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calponin
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semaphorin-plexin
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sema3a
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plexa
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semaphorin3a
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rab8
- 1.14.13.225
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plexins
- calponin
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semaphorin-plexin
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sema3a
- plexa
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semaphorin3a
- rab8
Reaction
Synonyms
MICAL, MICAL-1, MICAL-2, MICAL1, Mical2, MICAL2PV, MICAL3
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.14.13.225 - F-actin monooxygenase
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REACTION DIAGRAM
[F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O
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Mical post-translationally oxidizes the methionine 44 residue within the D-loop of actin, simultaneously severing filaments and decreasing polymerization
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[F-actin]-L-methionine + NADPH + O2 + H+
[F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O
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