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1.14.13.225: F-actin monooxygenase

This is an abbreviated version!
For detailed information about F-actin monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.225

Reaction

[F-actin]-L-methionine
+
NADPH
+
O2
+
H+
=
[F-actin]-L-methionine-(R)-S-oxide
+
NADP+
+
H2O

Synonyms

MICAL, MICAL-1, MICAL-2, MICAL1, Mical2, MICAL2PV, MICAL3

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.225 F-actin monooxygenase

Reference

Reference on EC 1.14.13.225 - F-actin monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zucchini, D.; Caprini, G.; Pasterkamp, R.J.; Tedeschi, G.; Vanoni, M.A.
Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1
Arch. Biochem. Biophys.
515
1-13
2011
Homo sapiens (Q8TDZ2), Homo sapiens
Manually annotated by BRENDA team
Vitali, T.; Maffioli, E.; Tedeschi, G.; Vanoni, M.A.
Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains
Arch. Biochem. Biophys.
593
24-37
2016
Homo sapiens (Q8TDZ2)
Manually annotated by BRENDA team
McDonald, C.A.; Liu, Y.Y.; Palfey, B.A.
Actin stimulates reduction of the MICAL-2 monooxygenase domain
Biochemistry
52
6076-6084
2013
Mus musculus (Q8BML1)
Manually annotated by BRENDA team
Hung, R.J.; Spaeth, C.S.; Yesilyurt, H.G.; Terman, J.R.
SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics
Nat. Cell Biol.
15
1445-1454
2013
Drosophila melanogaster (Q86BA1)
Manually annotated by BRENDA team
Grintsevich, E.E.; Yesilyurt, H.G.; Rich, S.K.; Hung, R.J.; Terman, J.R.; Reisler, E.
F-actin dismantling through a redox-driven synergy between Mical and cofilin
Nat. Cell Biol.
18
876-885
2016
Drosophila melanogaster (Q86BA1)
Manually annotated by BRENDA team
Hung, R.J.; Yazdani, U.; Yoon, J.; Wu, H.; Yang, T.; Gupta, N.; Huang, Z.; van Berkel, W.J.; Terman, J.R.
Mical links semaphorins to F-actin disassembly
Nature
463
823-827
2010
Drosophila melanogaster (Q86BA1)
Manually annotated by BRENDA team
Alqassim, S.S.; Urquiza, M.; Borgnia, E.; Nagib, M.; Amzel, L.M.; Bianchet, M.A.
Modulation of MICAL monooxygenase activity by its calponin homology domain: structural and mechanistic insights
Sci. Rep.
6
22176
2016
Mus musculus (Q8VDP3)
Manually annotated by BRENDA team
Hung, R.J.; Pak, C.W.; Terman, J.R.
Direct redox regulation of F-actin assembly and disassembly by Mical
Science
334
1710-1713
2011
Drosophila melanogaster (Q86BA1)
Manually annotated by BRENDA team
McGarry, D.J.; Armstrong, G.; Castino, G.; Mason, S.; Clark, W.; Shaw, R.; McGarry, L.; Blyth, K.; Olson, M.F.
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours
Cancer Lett.
519
226-236
2021
Homo sapiens (Q8TDZ2), Homo sapiens
Manually annotated by BRENDA team
Giarratana, N.; Conti, F.; La Rovere, R.; Gijsbers, R.; Carai, P.; Duelen, R.; Vervliet, T.; Bultynck, G.; Ronzoni, F.; Piciotti, R.; Costamagna, D.; Fulle, S.; Barravecchia, I.; Angeloni, D.; Torrente, Y.; Sampaolesi, M.
MICAL2 is essential for myogenic lineage commitment
Cell Death Dis.
11
654
2020
Mus musculus (Q8BML1)
Manually annotated by BRENDA team
Wang, F.; Chen, X.; Cheng, H.; Song, L.; Liu, J.; Caplan, S.; Zhu, L.; Wu, J.Y.
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking
EMBO Rep.
22
e52006
2021
Homo sapiens (O94851)
Manually annotated by BRENDA team
Yoon, J.; Wu, H.; Hung, R.J.; Terman, J.R.
Enhanced production of the Mical redox domain for enzymology and F-actin disassembly assays
Int. J. Mol. Sci.
22
1991
2021
Homo sapiens
Manually annotated by BRENDA team
Kim, J.; Lee, H.; Roh, Y.J.; Kim, H.U.; Shin, D.; Kim, S.; Son, J.; Lee, A.; Kim, M.; Park, J.; Hwang, S.Y.; Kim, K.; Lee, Y.K.; Jung, H.S.; Hwang, K.Y.; Lee, B.C.
Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3
IUCrJ
7
90-99
2020
Homo sapiens (Q7RTP6), Homo sapiens
Manually annotated by BRENDA team