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1.14.13.234: 5a,11a-dehydrotetracycline 5-monooxygenase

This is an abbreviated version!
For detailed information about 5a,11a-dehydrotetracycline 5-monooxygenase, go to the full flat file.

Reaction

5a,11a-dehydrotetracycline
+
NADPH
+
H+
+
O2
=
5a,11a-dehydrooxytetracycline
+
NADP+
+
H2O

Synonyms

12-dehydrotetracycline 5-monooxygenase, anhydrotetracycline oxygenase, OtcC, oxyS

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.234 5a,11a-dehydrotetracycline 5-monooxygenase

Reference

Reference on EC 1.14.13.234 - 5a,11a-dehydrotetracycline 5-monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vancurova, I.; Volc, J.; Flieger, M.; Neuzil, J.; Novotna, J.; Vlach, J.; Behal, V.
Isolation of pure anhydrotetracycline oxygenase from Streptomyces aureofaciens
Biochem. J.
253
263-267
1988
Kitasatospora aureofaciens
Manually annotated by BRENDA team
Miller, P.; Saturnelli, A.; Martin, J.; Mitscher, L.; Bohonos, N.
A new family of tetracycline precursors: N-demethylanhydrotetracyclines
Biochem. Biophys. Res. Commun.
16
285-291
1964
Kitasatospora aureofaciens, Streptomyces rimosus, Kitasatospora aureofaciens BC-41
Manually annotated by BRENDA team
Wang, P.; Bashiri, G.; Gao, X.; Sawaya, M.R.; Tang, Y.
Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis
J. Am. Chem. Soc.
135
7138-7141
2013
Streptomyces rimosus subsp. rimosus (L8EUQ6), Streptomyces rimosus subsp. rimosus ATCC 10970 (L8EUQ6)
Manually annotated by BRENDA team
Binnie, C.; Warren, M.; Butler, M.
Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis
J. Bacteriol.
171
887-895
1989
Streptomyces rimosus (Q55001)
Manually annotated by BRENDA team
Herbst, E.; Lee, A.; Tang, Y.; Snyder, S.; Cornish, V.
Heterologous catalysis of the final steps of tetracycline biosynthesis by Saccharomyces cerevisiae
ACS Chem. Biol.
16
1425-1434
2021
Streptomyces rimosus subsp. rimosus (L8EUQ6), Streptomyces rimosus subsp. rimosus DSM 40260 (L8EUQ6)
Manually annotated by BRENDA team