1.14.13.234: 5a,11a-dehydrotetracycline 5-monooxygenase
This is an abbreviated version!
For detailed information about 5a,11a-dehydrotetracycline 5-monooxygenase, go to the full flat file.
Reaction
Synonyms
12-dehydrotetracycline 5-monooxygenase, anhydrotetracycline oxygenase, OtcC, oxyS
ECTree
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Systematic Name
Systematic Name on EC 1.14.13.234 - 5a,11a-dehydrotetracycline 5-monooxygenase
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5a,11a-dehydrotetracycline,NADPH:oxygen oxidoreductase (5-hydroxylating)
The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalysing two successive monooxygenation reactions. It starts by catalysing the stereospecific hydroxylation of anhydrotetracycline at C-6 (EC 1.14.13.38). If the released product is captured by EC 1.3.98.4, 5a,11a-dehydrotetracycline dehydrogenase (OxyR), it is reduced to tetracycline. However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C-5, producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR, becomes oxytetracycline.