1.14.13.24: 3-hydroxybenzoate 6-monooxygenase
This is an abbreviated version!
For detailed information about 3-hydroxybenzoate 6-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.24
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1.14.13.24
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gentisate
-
flavoprotein
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flavin
-
fad
-
rhodococcus
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salicylate
-
hydroxylases
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jostii
-
2,5-dihydroxybenzoate
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maleylpyruvate
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para-hydroxylation
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alcaligenes
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nadh-dependent
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flavin-dependent
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ncimb
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near-uv
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fumarylpyruvate
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nadh-specific
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p-hydroxybenzoate
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regioselective
- 1.14.13.24
- gentisate
- flavoprotein
- flavin
- fad
- rhodococcus
- salicylate
- hydroxylases
- jostii
- 2,5-dihydroxybenzoate
- maleylpyruvate
-
para-hydroxylation
- alcaligenes
-
nadh-dependent
-
flavin-dependent
-
ncimb
-
near-uv
- fumarylpyruvate
-
nadh-specific
- p-hydroxybenzoate
-
regioselective
Reaction
Synonyms
3-HBA-6-hydroxylase, 3-hydroxybenzoate 6-hydroxylase, 3-hydroxybenzoate-6-hydroxylase, 3-hydroxybenzoic acid-6-hydroxylase, 3HB6H, m-hydroxybenzoate 6-hydroxylase, MNX2, Mnx2p, NagX, NarX, Ncgl2923, oxygenase, 3-hydroxybenzoate 6-mono-, XlnD
ECTree
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Substrates Products
Substrates Products on EC 1.14.13.24 - 3-hydroxybenzoate 6-monooxygenase
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REACTION DIAGRAM
2,3,4-trihydroxybenzoate + NADH + H+ + O2
2,3,4,6-tetrahydroxybenzoate + NAD+ + H2O
-
-
-
-
?
2,3-dihydroxybenzoate + NADH + H+ + O2
2,3,6-trihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3,5-dihydroxybenzoate + NADH + H+ + O2
2,3,5,6-tetrahydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxy-3-methylbenzoate + NAD(P)H + O2
2,5-dihydroxy-3-methylbenzoate + NAD(P)+ + H2O
-
-
-
?
3-hydroxy-4-aminobenzoate + NADH + H+ + O2
4-amino-2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxy-4-methoxybenzoate + NADH + H+ + O2
4-methoxy-2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxy-4-methylbenzoate + NAD(P)H + O2
2,5-dihydroxy-4-methylbenzoate + NAD(P)+ + H2O
the substrate is an intermediate in the degradation of 2,5-xylenol, higher activity with the recombinant His-tagged enzyme compared to the native enzyme
-
-
?
3-hydroxy-4-methylbenzoate + NADH + H+ + O2
4-methyl-2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxy-5-methylbenzoate + NAD(P)H + O2
2,5-dihydroxy-3-methylbenzoate + NAD(P)+ + H2O
the substrate is an intermediate in the degradation of 3,5-xylenol, higher activity with the recombinant His-tagged enzyme compared to the native enzyme, preferred substrate
-
-
?
4-fluoro-3-hydroxybenzoate + NADH + O2
4-fluoro-2,5-dihydroxybenzoate + NAD+ + H2O
-
36% of the reaction with 3-hydroxybenzoate
-
?
2,3,5-trihydroxybenzoate + NAD+ + H2O
-
10.5% of the reaction with 3-hydroxybenzoate
-
?
2,3-dihydroxybenzoate + NADH + O2
2,3,5-trihydroxybenzoate + NAD+ + H2O
-
10.5% of the reaction with 3-hydroxybenzoate
-
?
2,4,5-trihydroxybenzoate + NAD+ + H2O
-
9% of the reaction with 3-hydroxybenzoate
-
?
3,4-dihydroxybenzoate + NADH + O2
2,4,5-trihydroxybenzoate + NAD+ + H2O
-
9% of the reaction with 3-hydroxybenzoate
-
?
2,3,5-trihydroxybenzoate + NAD+ + H2O
-
7% of the reaction with 3-hydroxybenzoate
-
?
3,5-dihydroxybenzoate + NADH + O2
2,3,5-trihydroxybenzoate + NAD+ + H2O
-
7% of the reaction with 3-hydroxybenzoate
-
?
2,5-dihydroxy-3-methylbenzoate + NAD+ + H2O
-
31% of the reaction with 3-hydroxybenzoate
-
?
3-hydroxy-5-methylbenzoate + NADH + O2
2,5-dihydroxy-3-methylbenzoate + NAD+ + H2O
-
31% of the reaction with 3-hydroxybenzoate
-
?
gentisate + NAD(P)+ + H2O
-
-
i.e. 2,5-dihydroxybenzoate
-
?
3-hydroxybenzoate + NAD(P)H + H+ + O2
gentisate + NAD(P)+ + H2O
-
the small catabolic gene cluster nagR2-orf2I''KL in strain CJ2 may be multifunctional and is essential for the degradation of 3-hydroxybenzoate
i.e. 2,5-dihydroxybenzoate
-
?
2,5-dihydroxybenzoate + NAD(P)+ + H2O
-
i.e. gentisate
-
?
3-hydroxybenzoate + NAD(P)H + O2
2,5-dihydroxybenzoate + NAD(P)+ + H2O
the enzyme is involved in the degradation of 2,5-xylenol and 3,5-xylenol via the gentisate pathway, overview
-
-
?
3-hydroxybenzoate + NAD(P)H + O2
2,5-dihydroxybenzoate + NAD(P)+ + H2O
-
i.e. gentisate
-
?
3-hydroxybenzoate + NAD(P)H + O2
2,5-dihydroxybenzoate + NAD(P)+ + H2O
the enzyme is involved in the degradation of 2,5-xylenol and 3,5-xylenol via the gentisate pathway, overview
-
-
?
2,5-dihydroxybenzoate + NAD+ + H2O
-
i.e. gentisate
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
i.e. gentisate
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
r
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
the enzyme clearly prefers NADH as external electron donor over NADPH
-
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
NarX shows activity on 3-hydroxybenzoate rather than on salicylate
-
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
?
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
NarX shows activity on 3-hydroxybenzoate rather than on salicylate
-
-
?
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
i.e. gentisate
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
strictly specific for 3-hydroxybenzoate
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
key role in metabolism of aromatic compounds
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
-
-
-
-
?
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
-
r
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
-
?
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
i.e. gentisate
-
?
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
i.e. gentisate
-
?
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
-
r
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
-
r
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
-
r
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
the enzyme clearly prefers NADH as external electron donor over NADPH
-
-
?
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
?
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
-
-
-
?
additional information
?
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-
acts also on a number of analogs of 3-hydroxybenzoate substituted in the 2, 3, 5 and 6 positions
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-
?
additional information
?
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-
the enzyme shows no salicylate 5-hydroxylase activity
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-
?
additional information
?
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degradation of 2,5-xylenol and 3,5-xylenol in strain P25X depends on isozyme I, not isozyme II
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-
?
additional information
?
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degradation of 2,5-xylenol and 3,5-xylenol in strain P25X depends on isozyme I, not isozyme II
-
-
?
additional information
?
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the purified H6-NarX protein shows no detectable activity against the 3HBA structural analogues, including 2-hydroxybenzoate, i.e. salicylate, 4-hydroxybenzoate, or 4-substituted derivatives (4-CH3, 4-NH2, and 4-NO2) of 3-hydroxybenzoate
-
-
?
additional information
?
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-
the purified H6-NarX protein shows no detectable activity against the 3HBA structural analogues, including 2-hydroxybenzoate, i.e. salicylate, 4-hydroxybenzoate, or 4-substituted derivatives (4-CH3, 4-NH2, and 4-NO2) of 3-hydroxybenzoate
-
-
?
additional information
?
-
the purified H6-NarX protein shows no detectable activity against the 3HBA structural analogues, including 2-hydroxybenzoate, i.e. salicylate, 4-hydroxybenzoate, or 4-substituted derivatives (4-CH3, 4-NH2, and 4-NO2) of 3-hydroxybenzoate
-
-
?