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1.14.13.24: 3-hydroxybenzoate 6-monooxygenase

This is an abbreviated version!
For detailed information about 3-hydroxybenzoate 6-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.24

Reaction

3-hydroxybenzoate
+
NADH
+
H+
+
O2
=
2,5-Dihydroxybenzoate
+
NAD+
+
H2O

Synonyms

3-HBA-6-hydroxylase, 3-hydroxybenzoate 6-hydroxylase, 3-hydroxybenzoate-6-hydroxylase, 3-hydroxybenzoic acid-6-hydroxylase, 3HB6H, m-hydroxybenzoate 6-hydroxylase, MNX2, Mnx2p, NagX, NarX, Ncgl2923, oxygenase, 3-hydroxybenzoate 6-mono-, XlnD

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.24 3-hydroxybenzoate 6-monooxygenase

Substrates Products

Substrates Products on EC 1.14.13.24 - 3-hydroxybenzoate 6-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3,4-trihydroxybenzoate + NADH + H+ + O2
2,3,4,6-tetrahydroxybenzoate + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
2,3-dihydroxybenzoate + NADH + H+ + O2
2,3,6-trihydroxybenzoate + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
2,3-dihydroxybenzoate + NADH + O2
2,3,5-trihydroxybenzoate + NAD+ + H2O
show the reaction diagram
3,4-dihydroxybenzoate + NADH + H+ + O2
?
show the reaction diagram
-
very poor substrate
-
-
?
3,4-dihydroxybenzoate + NADH + O2
2,4,5-trihydroxybenzoate + NAD+ + H2O
show the reaction diagram
3,5-dihydroxybenzoate + NADH + H+ + O2
2,3,5,6-tetrahydroxybenzoate + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
3,5-dihydroxybenzoate + NADH + O2
2,3,5-trihydroxybenzoate + NAD+ + H2O
show the reaction diagram
3-aminobenzoate + NAD(P)H + O2
?
show the reaction diagram
3-bromobenzoate + NAD(P)H + O2
?
show the reaction diagram
3-chlorobenzoate + NAD(P)H + O2
?
show the reaction diagram
-
-
-
?
3-fluorobenzoate + NAD(P)H + O2
?
show the reaction diagram
-
-
-
?
3-hydroxy-3-methylbenzoate + NAD(P)H + O2
2,5-dihydroxy-3-methylbenzoate + NAD(P)+ + H2O
show the reaction diagram
-
-
-
?
3-hydroxy-4-aminobenzoate + NADH + H+ + O2
4-amino-2,5-dihydroxybenzoate + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
3-hydroxy-4-methoxybenzoate + NADH + H+ + O2
4-methoxy-2,5-dihydroxybenzoate + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
3-hydroxy-4-methylbenzoate + NAD(P)H + O2
2,5-dihydroxy-4-methylbenzoate + NAD(P)+ + H2O
show the reaction diagram
the substrate is an intermediate in the degradation of 2,5-xylenol, higher activity with the recombinant His-tagged enzyme compared to the native enzyme
-
-
?
3-hydroxy-4-methylbenzoate + NADH + H+ + O2
4-methyl-2,5-dihydroxybenzoate + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
3-hydroxy-5-methylbenzoate + NAD(P)H + O2
2,5-dihydroxy-3-methylbenzoate + NAD(P)+ + H2O
show the reaction diagram
the substrate is an intermediate in the degradation of 3,5-xylenol, higher activity with the recombinant His-tagged enzyme compared to the native enzyme, preferred substrate
-
-
?
3-hydroxy-5-methylbenzoate + NADH + O2
2,5-dihydroxy-3-methylbenzoate + NAD+ + H2O
show the reaction diagram
3-hydroxybenzoate + NAD(P)H + H+ + O2
gentisate + NAD(P)+ + H2O
show the reaction diagram
3-hydroxybenzoate + NAD(P)H + O2
2,5-dihydroxybenzoate + NAD(P)+ + H2O
show the reaction diagram
3-hydroxybenzoate + NADH + H+ + O2
2,5-dihydroxybenzoate + NAD+ + H2O
show the reaction diagram
3-hydroxybenzoate + NADH + O2
2,5-dihydroxybenzoate + NAD+ + H2O
show the reaction diagram
3-hydroxybenzoate + NADPH + H+ + O2
2,5-dihydroxybenzoate + NADP+ + H2O
show the reaction diagram
3-methylthiobenzoate + NAD(P)H + O2
?
show the reaction diagram
-
-
-
?
4-fluoro-3-hydroxybenzoate + NADH + O2
4-fluoro-2,5-dihydroxybenzoate + NAD+ + H2O
show the reaction diagram
-
36% of the reaction with 3-hydroxybenzoate
-
?
additional information
?
-