1.14.13.242: 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

This is an abbreviated version!
For detailed information about 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.242

1.14.13.242

flavin

flavoproteins

fad

hydroxylases

mesorhizobium

flavoenzyme

electrophilic

loti

acyclic

flavin-dependent

ring-cleavage

hydride

isoalloxazine

Reaction

3-Hydroxy-2-methylpyridine-5-carboxylate

Synonyms

2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase, 2-methyl-3-hydroxypyridine 5-carboxylic acid oxygenase, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, 3-hydroxy-2-methylpyridine carboxylate dioxygenase, 3-hydroxy-2-methylpyridinecarboxylate dioxygenase, EC 1.14.12.4, methylhydroxypyridine carboxylate dioxygenase, methylhydroxypyridinecarboxylate oxidase, MHPCO, mlr6788

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.242 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

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Results	in table
7	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
22	Cofactor
8	Crystallization (Commentary)
10	General Information
1	IC50 Value
8	Inhibitors
3	kcat/KM [mM/s]
2	Ki Value [mM]
21	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
42	Organism
1	Oxidation Stability
3	Pathway
3	pH Optimum
19	Protein Variants
7	Purification (Commentary)
6	Reaction
3	Reaction Type
25	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
46	Substrates and Products (Substrate)
6	Subunits
38	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.13.242 - 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

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1-deaza-FAD

Pseudomonas sp.

439056

5-hydroxynicotinic acid

5-pyridoxic acid

6-Methylnicotinate

6-methylnicotinic acid

Pseudomonas sp.

competitive with 3-hydroxy-2-methylpyridine-5-carboxylate

439054

NAD+

Pseudomonas sp.

binds competitively with O2, but not with NADH

439057

p-chloromercuribenzoate

Pseudomonas sp.

0.05 mM, quick and complete inhibition

439054