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1.14.13.242: 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

This is an abbreviated version!
For detailed information about 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.242

Reaction

3-Hydroxy-2-methylpyridine-5-carboxylate
+
NAD(P)H
 +
H+
 +
O2
=
2-(acetamidomethylidene)succinate
 +
NAD(P)+

Synonyms

2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase, 2-methyl-3-hydroxypyridine 5-carboxylic acid oxygenase, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, 3-hydroxy-2-methylpyridine carboxylate dioxygenase, 3-hydroxy-2-methylpyridinecarboxylate dioxygenase, EC 1.14.12.4, methylhydroxypyridine carboxylate dioxygenase, methylhydroxypyridinecarboxylate oxidase, MHPCO, mlr6788

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.242 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

Reference

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Reference on EC 1.14.13.242 - 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sparrow, L.G.; Ho, P.P.K.; Sundaram, T.K.; Zach, D.; Nyns, E.J.; Snell, E.E.
The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring
J. Biol. Chem.
244
2590-2600
1969
Pseudomonas sp.
Manually annotated by BRENDA team
Kishore, G.M.; Snell, E.E.
Interaction of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase with FAD, substrates, and analogues. Spectral and fluorescence investigations
J. Biol. Chem.
256
4234-4240
1981
Pseudomonas sp.
Manually annotated by BRENDA team
Kishore, G.M.; Snell, E.E.
Kinetic investigations on a flavoprotein oxygenase, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
J. Biol. Chem.
256
4228-4233
1981
Pseudomonas sp.
Manually annotated by BRENDA team
Chaiyen, P.; Ballou, D.P.; Massey, V.
Gene cloning, sequence analysis, and expression of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
Proc. Natl. Acad. Sci. USA
94
7233-7238
1997
Pseudomonas sp. (O08453), Pseudomonas sp.
Manually annotated by BRENDA team
Chaiyen, P.; Brissette, P.; Ballou, D.P.; Massey, V.
Reaction of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase with N-methyl-5-hydroxynicotinic acid: studies on the mode of binding, and Protonation Status of the Substrate
Biochemistry
36
13856-13864
1997
Pseudomonas sp.
Manually annotated by BRENDA team
Chaiyen, P.; Brissette, P.; Ballou, D.P.; Massey, V.
Unusual mechanism of oxygen atom transfer and product rearrangement in the catalytic reaction of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
Biochemistry
36
8060-8070
1997
Pseudomonas sp.
Manually annotated by BRENDA team
Chaiyen, P.; Brissette, P.; Ballou, D.P.; Massey, V.
Thermodynamics and reduction kinetics properties of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
Biochemistry
36
2612-2621
1997
Pseudomonas sp.
Manually annotated by BRENDA team
Oonanant, W.; Sucharitakul, J.; Yuvaniyama, J.; Chaiyen, P.
Crystallization and preliminary x-ray crystallographic analysis of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase from Pseudomonas sp. MA-1
Acta Crystallogr. Sect. F
61
312-314
2005
Pseudomonas sp.
Manually annotated by BRENDA team
Chaiyen, P.; Sucharitakul, J.; Svasti, J.; Entsch, B.; Massey, V.; Ballou, D.P.
Use of 8-substituted-FAD analogues to investigate the hydroxylation mechanism of the flavoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
Biochemistry
43
3933-3943
2004
Pseudomonas sp.
Manually annotated by BRENDA team
McCulloch, K.; Mukherjee, T.; Begley, T.; Ealick, S.
Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications
Biochemistry
48
4139-4149
2009
Mesorhizobium loti (Q988D3)
Manually annotated by BRENDA team
Tian, B.; Strid, A.; Eriksson, L.A.
Catalytic roles of active-site residues in 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase: an ONIOM/DFT study
J. Phys. Chem. B
115
1918-1926
2011
Mesorhizobium loti, Mesorhizobium loti MAFF303099
Manually annotated by BRENDA team
Luanloet, T.; Sucharitakul, J.; Chaiyen, P.
Selectivity of substrate binding and ionization of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
FEBS J.
282
3107-3125
2015
Pseudomonas sp. MA-1
Manually annotated by BRENDA team
Kobayashi, J.; Yoshida, H.; Yagi, T.; Kamitori, S.; Hayashi, H.; Mizutani, K.; Takahashi, N.; Mikami, B.
Role of the Tyr270 residue in 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti
J. Biosci. Bioeng.
123
154-162
2017
Mesorhizobium loti (Q988D3), Mesorhizobium loti, Mesorhizobium loti MAFF 303099 (Q988D3), Mesorhizobium loti MAFF303099 (Q988D3)
Manually annotated by BRENDA team
Tian, B.; Tu, Y.; Strid, A.; Eriksson, L.A.
Hydroxylation and ring-opening mechanism of an unusual flavoprotein monooxygenase, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase a theoretical study
Chemistry
16
2557-2566
2010
Mesorhizobium loti (Q988D3), Mesorhizobium loti MAFF 303099 (Q988D3)
Manually annotated by BRENDA team
Yuan, B.; Yokochi, N.; Yoshikane, Y.; Ohnishi, K.; Yagi, T.
Molecular cloning, identification and characterization of 2-methyl-3-hydroxypyridine-5-carboxylic-acid-dioxygenase-coding gene from the nitrogen-fixing symbiotic bacterium Mesorhizobium loti
J. Biosci. Bioeng.
102
504-510
2006
Mesorhizobium loti (Q988D3), Mesorhizobium loti, Mesorhizobium loti MAFF 303099 (Q988D3)
Manually annotated by BRENDA team
Lazar, J.T.; Shuvalova, L.; Rosas-Lemus, M.; Kiryukhina, O.; Satchell, K.J.F.; Minasov, G.
Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases
Acta Crystallogr. F Struct. Biol. Commun.
75
507-514
2019
Mesorhizobium japonicum (Q988D3), Mesorhizobium japonicum, Mesorhizobium japonicum CECT 9101 (Q988D3)
Manually annotated by BRENDA team
Lazar, J.T.; Shuvalova, L.; Rosas-Lemus, M.; Kiryukhina, O.; Satchell, K.J.F.; Minasov, G.
Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases
Acta Crystallogr. Sect. F
75
507-514
2019
Mesorhizobium japonicum (Q988D3), Mesorhizobium japonicum, Mesorhizobium japonicum LMG 29417 (Q988D3), Mesorhizobium japonicum CECT 9101 (Q988D3)
Manually annotated by BRENDA team