Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
axenic, high enzyme expression level
brenda
-
brenda
-
isozyme NOS3
brenda
-
-
brenda
-
brenda
-
iNOS
brenda
-
brenda
-
-
brenda
-
-
brenda
high expression
brenda
-
-
brenda
-
main nervous structures (buccal nerve and nerve plate) in the bud of the tentacle
brenda
-
cell line ME-180, constitutive expression
brenda
-
-
brenda
-
two populations of NADPH diaphorase-positive neurons exist in the human claustrustrum. One is comprised of large and medium cells consistent with a projection neuron phenotype, the other is represented by small cells resembling the interneuron phenotype as defined by previous Golgi impregnation studies. NADPH diaphorase-reactive neurons are heterogenously distributed throughout the claustrum
brenda
-
iNOS
brenda
-
bone marrow-derived
brenda
-
brenda
-
-
brenda
-
mainly in the lateral soma rind, surrounding the sensory glomeruli, partially in association with the antennal mechanosensory and motor neuropil
brenda
-
nNOS
brenda
-
-
brenda
-
NADPH-diaphorase activity is found in the midpiece of the spermatozoa tail and epithelial cells of all intratesticular and excurrent ducts analyzed, except for nonciliated cells of the efferent ductules. Immunostaining shows cell-specific localization in the efferent ductules and region- and cell-specific localization in the epididymal duct
brenda
-
brenda
-
brenda
-
synaptosomal fraction
brenda
-
brenda
-
cell line A-172, american type
brenda
-
brenda
-
-
brenda
highest expression in hemocytes, followed by the tissues of hepatopancreas, brain and intestine. Relatively low transcriptional levels are detected in the tissues of eyestalk, gill, heart and muscle
brenda
-
brenda
-
brenda
-
leaf extract
brenda
-
-
brenda
-
constitutive expression of full length nitric oxide synthase isoforms. Lymphocytes express more inducible nitric oxide synthase transcripts and protein than neuronal nitric oxide synthase and endothelial nitric oxide synthase
brenda
-
isozyme NOS1
brenda
-
NADPH-diaphorase is found in large and small neurons in the sensory, autonomic, and motor nuclei. In contrast to NADPH-diaphorase, nitric oxide synthase in the corresponding nuclei is always present in smaller quantities of mainly smaller neurons. In some nuclei (the nucleus ambiguus, the nucleus of the hypoglossal nerve) containing large numbers of NADPH-diaphorase-positive neurons, nitric oxide synthase immunoreactive cells are particularly rare
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
constitutive expression of full length nitric oxide synthase isoforms. Isolated monocytes express more endothelial nitric oxide synthase transcript and protein as compared to neuronal nitric oxide synthase and inducible nitric oxide synthase
brenda
-
brenda
-
three isoforms of nitric oxide synthase are mainly localized in the uterine luminal and glandular epithelium and myometrium, and the intensity of immunostaining for inducible nitric oxide synthase and endothelial nitric oxide synthase increases gradually with temporal development of the postnatal uterus. The total nitric oxide synthase and inducible nitric oxide synthase activities are significantly increased at postnatal days 21 and 35. Although constitutive nitric oxide synthase activity is increased at postnatal day 21, it decreases subsequently at postnatal day 35. Inducible nitric oxide synthase protein expression is significantly increased at postnatal days 21 and 35
brenda
-
type I neurons are generated during early corticogenesis, whereas type II cells are produced over a wide prenatal time window persisting until birth. Type II nitrinergic neurons may undergo a period of development/differentiation, for over 1 month, before being NADPH-diaphorase reactive
brenda
-
-
brenda
high expression
brenda
constitutive expression of Ca22+/calmodulin-dependent neuronal nitric oxide synthase in the central and peripheral nervous system
brenda
-
NOS1
brenda
of central ganglia
brenda
-
nNOS
brenda
-
-
brenda
high expression
brenda
-
-
brenda
-
brenda
-
constitutive expression of full length nitric oxide synthase isoforms with the highest expression of inducible nitric oxide synthase in comparison to neuronal nitric oxide synthase and endothelial nitric oxide synthase
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
n the skin, eNOS is present in the epidermal layer, hair follicles and also in the endothelial cells lining the blood vessels
brenda
-
brenda
-
brenda
-
distribution, overview, before and after axotomy and fibroblast growth factor-2 application
brenda
-
-
brenda
-
-
brenda
-
i.e. HUVEC cells
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
brenda
-
three isoforms of nitric oxide synthase are mainly localized in the uterine luminal and glandular epithelium and myometrium, and the intensity of immunostaining for inducible nitric oxide synthase and endothelial nitric oxide synthase increases gradually with temporal development of the postnatal uterus. The total nitric oxide synthase and inducible nitric oxide synthase activities are significantly increased at postnatal days 21 and 35. Although constitutive nitric oxide synthase activity is increased at postnatal day 21, it decreases subsequently at postnatal day 35. Inducible nitric oxide synthase protein expression is significantly increased at postnatal days 21 and 35
brenda
-
brenda
-
Pseudomonas aeruginosa stimulates expression of inducible nitric oxide synthase by A-549 cells
brenda
-
-
brenda
-
isoform I
brenda
-
-
brenda
-
isoform I
brenda
-
-
-
brenda
-
isoform I
brenda
-
brenda
-
thoracic, muscle
brenda
-
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
isoform I
brenda
-
Ca2+-dependent isoform
brenda
-
neuronal enzyme
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
brenda
-
-
440190, 440191, 440192, 440196, 440197, 440198, 440203, 440210, 440212, 440213, 440220, 440228, 440232, 440236, 671278, 686293 brenda
-
brenda
-
isoform I
brenda
-
Ca2+-dependent isoform
brenda
-
neuronal enzyme
brenda
-
nNOS
brenda
nNOS is the predominant isozyme in brain
brenda
-
from rats with unilateral depletion of dopamine in the substantia nigra compacta treated with L-DOPA at 30 mg/kg body weight for 34 days, nNOS expression is restricted to neurons
brenda
hypothalamic paraventricular nucleus and tanycytes
brenda
visual cortex, use of the NADPH-d histochemistry technique to evaluate the expression of NOS across the nervous system
brenda
-
-
-
brenda
-
-
-
brenda
-
Ca2+-dependent isoform
-
brenda
-
from rats with unilateral depletion of dopamine in the substantia nigra compacta treated with L-DOPA at 30 mg/kg body weight for 34 days, nNOS expression is restricted to neurons
-
brenda
-
hypothalamic paraventricular nucleus and tanycytes
-
brenda
-
visual cortex, use of the NADPH-d histochemistry technique to evaluate the expression of NOS across the nervous system
-
brenda
-
-
brenda
-
isoform I
brenda
-
-
brenda
-
cerebrum shows higher activity than cerebellum
brenda
-
-
brenda
-
brenda
-
cerebrum shows higher activity than cerebellum
brenda
-
cerebrum shows higher activity than cerebellum
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
-
the localization of NADPH-diaphorase and NO synthase is identical in the snail nervous system
brenda
-
-
brenda
-
brenda
the localization of NADPH-diaphorase and NO synthase is identical in the snail nervous system
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
nNOS
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
nNOS
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
iNOS is more frequently expressed in osteoarthritic than in normal chondrocytes, iNOS expression and activity in osteoarthritic chondrocytes is sub-maximal
brenda
nNOS is more frequently expressed in normal than in osteoarthritic chondrocytes
brenda
-
-
brenda
-
-
brenda
dental papilla cells (DPCs) are mesenchymal cells that are surrounded by the enamel organ during tooth development
brenda
-
dental papilla cells (DPCs) are mesenchymal cells that are surrounded by the enamel organ during tooth development
-
brenda
-
-
brenda
human umbilical vein endothelial cells
brenda
-
NOS3
brenda
-
brenda
-
-
brenda
-
-
brenda
-
constitutive, from pulmonary artery
brenda
-
isoform III
brenda
-
aorta, cell culture
brenda
comparison of endothelial and neuronal isoform
brenda
-
-
brenda
-
brenda
-
-
brenda
-
umbilical vein cells
brenda
-
isoform III
brenda
-
liver, lung, adrenal glandcolon, isoform II
brenda
-
lung, uterus, stomach
brenda
-
endothelial enzyme
brenda
-
specific isozyme eNOS
brenda
-
vascular, constitutive expression of the endothelial isozyme in endothelial cells
brenda
-
-
brenda
-
isoform III
brenda
-
aorta, cell culture
brenda
-
liver, lung, adrenal glandcolon, isoform II
brenda
-
eNOS, endothelial cells of blood vessels
brenda
-
-
brenda
-
isoform III
brenda
-
liver, lung, adrenal glandcolon, isoform II
brenda
-
lung, uterus, stomach
brenda
-
endothelial enzyme
brenda
-
-
-
brenda
-
isoform III
brenda
-
lung, uterus, stomach
brenda
-
-
brenda
-
brenda
coeliac ganglia
brenda
-
coeliac ganglia
-
brenda
-
subesophageal and prothoracic
brenda
-
eNOS
brenda
-
brenda
-
-
brenda
-
isoform II
brenda
-
isoform II
brenda
-
brenda
-
isoform II
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
brenda
-
estradiol regulates the nitrergic system in the supraoptic and paraventricular hypothalamic nuclei under acute osmotic stress conditions, but the effects specifically depend on the anatomical subregions and different estrogen receptors
brenda
neurons of several nuclei of the hypothalamus, such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN)
brenda
-
neurons of several nuclei of the hypothalamus, such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN)
-
brenda
-
macula densa cells, isoform I
brenda
-
anterior, iNOS
brenda
-
-
brenda
-
-
brenda
-
brenda
-
renal cortex
brenda
-
macula densa cells, isoform I
brenda
-
renal cortex
-
brenda
-
macula densa cells, isoform I
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
inducible isoform
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
temporal expression of hepatic iNOS in liver cirrhosis, induced in rats by chronic bile duct ligation, overview
brenda
-
-
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
alveolar
brenda
-
-
brenda
-
in liver, lung, kidney, isoform II
brenda
-
inducible enzyme
brenda
-
NOS2
brenda
-
-
brenda
-
in liver, lung, kidney, isoform II
brenda
-
RAW 264.7 cells
brenda
RAW 264.7 cells
brenda
-
Ca2+-independent form
brenda
-
cytokine-activated
brenda
cytokine-activated
brenda
-
bone marrow-derived
brenda
-
iNOS
brenda
-
-
brenda
-
in liver, lung, kidney, isoform II
brenda
-
cytokine-activated
brenda
-
inducible enzyme
brenda
iNOS is the predominant isozyme in macrophages
brenda
-
-
-
brenda
-
strong histohemical labelling in sensory fibre branches of segmental nerves and in each of the sensory longitudinal axon bundles of ventral nerve cord ganglia. NADPH-diaphorase positive central sensory cells can be identified from among which the putative tactile receptors are characterized by constant, strong staining
brenda
-
isozyme NOS1
brenda
-
strong histohemical labelling in sensory fibre branches of segmental nerves and in each of the sensory longitudinal axon bundles of ventral nerve cord ganglia. NADPH-diaphorase positive central sensory cells can be identified from among which the putative tactile receptors are characterized by constant, strong staining
brenda
-
-
brenda
comparison of endothelial and neuronal isoform
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
peripheral nitrergic nerves, isoform I
brenda
-
isozyme NOS1
brenda
-
amacrine
brenda
-
-
brenda
-
brenda
-
central nervous system, natural variant with 105-amino acid deletion in the heme-binding domain
brenda
-
neuronal NOS, nNOS
brenda
-
nNOS
brenda
-
-
brenda
-
brenda
-
peripheral nitrergic nerves, isoform I
brenda
-
neuronal NOS, nNOS
brenda
neurons of several nuclei of the hypothalamus, such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN)
brenda
nitrergic neurons in the rat stomach, the myenteric cell bodies have single axons, type I morphology and a wide range of sizes. Nitrergic terminals do not provide baskets of terminals around myenteric neurons. The nitrergic neuron populations in the stomach supply the muscle layers and intramural arteries, but, unlike in the intestine, gastric interneurons do not express nNOS
brenda
the NADPH-d histochemistry stains a selective population of neurons in the brain. The staining allows the visualization of the dendritic tree, resembling a Golgi impregnation, and the cells are distributed sparsely in the cortical tissue, allowing their unbiased identification and reconstruction, quantitative analysis, overview
brenda
-
nitrergic neurons in the rat stomach, the myenteric cell bodies have single axons, type I morphology and a wide range of sizes. Nitrergic terminals do not provide baskets of terminals around myenteric neurons. The nitrergic neuron populations in the stomach supply the muscle layers and intramural arteries, but, unlike in the intestine, gastric interneurons do not express nNOS
-
brenda
-
-
-
brenda
-
neurons of several nuclei of the hypothalamus, such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN)
-
brenda
-
the NADPH-d histochemistry stains a selective population of neurons in the brain. The staining allows the visualization of the dendritic tree, resembling a Golgi impregnation, and the cells are distributed sparsely in the cortical tissue, allowing their unbiased identification and reconstruction, quantitative analysis, overview
-
brenda
-
peripheral nitrergic nerves, isoform I
brenda
-
of central ganglia
brenda
-
polymorphonuclear
brenda
-
peritoneal polymorphonuclear
brenda
-
polymorphonuclear neutrophils, PMN
brenda
from rats at different ages. Odontoblasts are strongly stained for NADPH-d. The staining intensity of odontoblasts near the future cusp and root is higher than that of other locations of the first molar. Odontoblasts in the first molar from 3-month-old rats are also positive for NADPH-d staining. Odontoblasts in the first molar from 8-month-old rats are weakly positive for NADPH-d staining. Semiquantitative evaluation results of NADPH-d staining suggests that NOS may be involved in the differentiation and function of odontoblasts
brenda
-
from rats at different ages. Odontoblasts are strongly stained for NADPH-d. The staining intensity of odontoblasts near the future cusp and root is higher than that of other locations of the first molar. Odontoblasts in the first molar from 3-month-old rats are also positive for NADPH-d staining. Odontoblasts in the first molar from 8-month-old rats are weakly positive for NADPH-d staining. Semiquantitative evaluation results of NADPH-d staining suggests that NOS may be involved in the differentiation and function of odontoblasts
-
brenda
-
-
brenda
-
islet cells, isoform I
brenda
-
islet cells, isoform I
brenda
-
islet cells, isoform I
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
distribution, overview, in retinorecipient tectal layer, before and after axotomy and fibroblast growth factor-2 application
brenda
-
constitutive, soluble form
brenda
-
constitutive, soluble form
-
brenda
-
isozyme NOS3
brenda
-
-
brenda
-
lumbar spinal cord
brenda
-
isoform I
brenda
-
nNOS, nerve cell bodies and neuronal fibers
brenda
-
isoform I
brenda
-
isoform I
brenda
-
red pulp, eosinophils and neutrophils, isoform II
brenda
-
red pulp, eosinophils and neutrophils, isoform II
brenda
-
iNOS
brenda
-
red pulp, eosinophils and neutrophils, isoform II
brenda
nitrergic neurons in the rat stomach comprising similar proportions of myenteric neurons, about 30%, in all gastric regions, e.g. the longitudinal, circular and oblique layers of the external muscle, the muscularis mucosae and arteries within the gastric wall
brenda
-
nitrergic neurons in the rat stomach comprising similar proportions of myenteric neurons, about 30%, in all gastric regions, e.g. the longitudinal, circular and oblique layers of the external muscle, the muscularis mucosae and arteries within the gastric wall
-
brenda
-
isoform I
brenda
-
isoform I
brenda
-
isoform I
brenda
-
brenda
-
-
-
brenda
-
main nervous structures (buccal nerve and nerve plate) in the bud of the tentacle
brenda
high expression in cephalic tentacle
brenda
-
NADPH-diaphorase activity is found in the midpiece of the spermatozoa tail and epithelial cells of all intratesticular and excurrent ducts analyzed, except for nonciliated cells of the efferent ductules. Immunostaining shows cell-specific localization in the efferent ductules and region- and cell-specific localization in the epididymal duct
brenda
eNOS immunoreactivity is detected in germ cells, Sertoli cells, Leydig cells and vascular endothelial cells of the testis
brenda
iNOS positive cells are detected in seminiferous epithelial cells, especially in germ cells of the testis
brenda
additional information
-
3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
brenda
additional information
-
localization and distribution of nitric oxide synthase and other neuronal markers in the podia of Holothuria arguinensis, detailed overview. The podia terminal end is the most specialized area and is characterized by a specific nervous arrangement, consisting of a distinct nerve plate, rich in cells and fibers containing potential sensory cells staining positively for neuronal markers. In sea cucumbers, cells with morphological characteristics typical of sensory cells have been described in the tentacles, tube feet, and papillae. NADPH-diaphorase histochemistry and NOS immunohistochemistry. The NADPH-diaphorase staining and the anti-NOS antibody show an overall similar distribution in the tentacle. In the stem, the longitudinal buccal nerve and the buccal nerve are strongly reactive to both markers. The mesothelium is also positive for NADPH-d and anti-NOS. In the bud, the two methods reveal that NOS is present in both the buccal nerve and mesothelium
brenda
additional information
-
3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
brenda
additional information
-
3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
brenda
additional information
-
3 distinct isoforms: 1. a membrane-associated, constitutive enzyme from tha vascular endothelium, 2. a soluble, constitutive enzyme from neuronal cells, 3. an endotoxin- and cytokine-inducible enzyme exemplified by that from murine macrophages
brenda
additional information
-
activity of constitutive enzymes is regulated by binding of calmodulin and Ca2+, the inducible enzyme is regulated by binding of calmodulin, not by Ca2+
brenda
additional information
-
nNOS splicing variants tissue distribution, immunohistochemic analysis, overview
brenda
additional information
-
no activity in gill, intestine, and liver
brenda
additional information
-
3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
brenda
additional information
-
3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
brenda
additional information
expression analysis in isolated hepatocytes, healthy liver, and cirrhotic liver, overview
brenda
additional information
-
nNOS splicing variants tissue distribution, immunohistochemic analysis, overview
brenda
additional information
determination of NADPH diaphorase staining in preganglionic terminals, staining generally ascribed to NADH diaphorase activity in aldehyde-treated tissues
brenda
additional information
distribution of NADPH-d-positive neurons and fibers in the paraventricular nucleus (PVN) after saline and leptin treatment, in situ overview
brenda
additional information
-
distribution of NADPH-d-positive neurons and fibers in the paraventricular nucleus (PVN) after saline and leptin treatment, in situ overview
brenda
additional information
immunohistochemic enzyme and NADPH histochemic analysis, distributions of nNOS neurons and their terminals throughout the rat stomach, overview. NADPH diaphorase is the colour reaction that reveals the presence of NADPH oxidases, and because nNOS is a NADPH oxidase, it is revealed by NADPHd histochemistry
brenda
additional information
NO synthase (NOS) immunohistochemic analysis and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining in vivo in rat odontoblasts. The expression of neuronal NOS and endothelial NOS is upregulated during the odontoblastic differentiation of DPCs
brenda
additional information
pattern of NADPH-d neuropil staining and pattern of astrocyte reactivity, qualitative and quantitative analysis, overview. MeHg-intoxicated animals display a significant decrease of NADPH-d neuropil reactivity across the visual cortex when compared to controls
brenda
additional information
-
NO synthase (NOS) immunohistochemic analysis and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining in vivo in rat odontoblasts. The expression of neuronal NOS and endothelial NOS is upregulated during the odontoblastic differentiation of DPCs
-
brenda
additional information
-
immunohistochemic enzyme and NADPH histochemic analysis, distributions of nNOS neurons and their terminals throughout the rat stomach, overview. NADPH diaphorase is the colour reaction that reveals the presence of NADPH oxidases, and because nNOS is a NADPH oxidase, it is revealed by NADPHd histochemistry
-
brenda
additional information
-
determination of NADPH diaphorase staining in preganglionic terminals, staining generally ascribed to NADH diaphorase activity in aldehyde-treated tissues
-
brenda
additional information
-
3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
-
brenda
additional information
-
distribution of NADPH-d-positive neurons and fibers in the paraventricular nucleus (PVN) after saline and leptin treatment, in situ overview
-
brenda
additional information
-
pattern of NADPH-d neuropil staining and pattern of astrocyte reactivity, qualitative and quantitative analysis, overview. MeHg-intoxicated animals display a significant decrease of NADPH-d neuropil reactivity across the visual cortex when compared to controls
-
brenda
additional information
no expression in salivary glands and the gland of Leiblein
brenda
additional information
-
no expression in salivary glands and the gland of Leiblein
brenda
additional information
-
3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
brenda
additional information
-
immunohistochemic analysis of enzyme distribution, overview
brenda