Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.13.39: nitric-oxide synthase (NADPH)

This is an abbreviated version!
For detailed information about nitric-oxide synthase (NADPH), go to the full flat file.

Word Map on EC 1.14.13.39

Reaction

2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O

Synonyms

bacterial nitric oxide synthase, bacterial nitric-oxide synthase, bNOS, bsNOS, cb-NOS, cytokine inducible NOS, DNOS, e-NOS, EC-NOS, endothelial nitric oxide synthase, endothelial nitric-oxide synthase, endothelial NO synthase, endothelial NOS, endothelium-derived relaxation factor-forming enzyme, endothelium-derived relaxing factor synthase, eNOS, i-NOS, inducible nitric oxide synthase, inducible nitric-oxide synthase, inducible NO synthase, inducible NOS, iNOS, mitochondrial NO synthase, mitochondrial-specific nitric oxide synthase, mtNOS, n-NOS, NADPH diaphorase, NADPH-d, NADPH-diaphorase, NADPHd, neuronal nitric oxide synthase, neuronal nitric-oxide synthase, neuronal NO synthase, neuronal NOS, nicotinamide adenine dinucleotide phosphate-diaphorase, nitric oxid synthase, nitric oxide synthase, nitric oxide synthase-like protein, nitric oxide synthetase, nitric-oxide synthase, nNOS, nNOSalpha, NO synthase, NO synthase type I, NO synthase type II, NO synthase type III, NO-synthase, NOS, NOS I, NOS-2, NOS1, NOS2, NOS3, synthetase, nitric oxide

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.39 nitric-oxide synthase (NADPH)

Source Tissue

Source Tissue on EC 1.14.13.39 - nitric-oxide synthase (NADPH)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
axenic, high enzyme expression level
Manually annotated by BRENDA team
-
isozyme NOS3
Manually annotated by BRENDA team
-
iNOS
Manually annotated by BRENDA team
-
main nervous structures (buccal nerve and nerve plate) in the bud of the tentacle
Manually annotated by BRENDA team
-
cell line ME-180, constitutive expression
Manually annotated by BRENDA team
-
two populations of NADPH diaphorase-positive neurons exist in the human claustrustrum. One is comprised of large and medium cells consistent with a projection neuron phenotype, the other is represented by small cells resembling the interneuron phenotype as defined by previous Golgi impregnation studies. NADPH diaphorase-reactive neurons are heterogenously distributed throughout the claustrum
Manually annotated by BRENDA team
-
iNOS
Manually annotated by BRENDA team
-
bone marrow-derived
Manually annotated by BRENDA team
-
mainly in the lateral soma rind, surrounding the sensory glomeruli, partially in association with the antennal mechanosensory and motor neuropil
Manually annotated by BRENDA team
-
NADPH-diaphorase activity is found in the midpiece of the spermatozoa tail and epithelial cells of all intratesticular and excurrent ducts analyzed, except for nonciliated cells of the efferent ductules. Immunostaining shows cell-specific localization in the efferent ductules and region- and cell-specific localization in the epididymal duct
Manually annotated by BRENDA team
-
synaptosomal fraction
Manually annotated by BRENDA team
-
cell line A-172, american type
Manually annotated by BRENDA team
highest expression in hemocytes, followed by the tissues of hepatopancreas, brain and intestine. Relatively low transcriptional levels are detected in the tissues of eyestalk, gill, heart and muscle
Manually annotated by BRENDA team
-
leaf extract
Manually annotated by BRENDA team
-
constitutive expression of full length nitric oxide synthase isoforms. Lymphocytes express more inducible nitric oxide synthase transcripts and protein than neuronal nitric oxide synthase and endothelial nitric oxide synthase
Manually annotated by BRENDA team
-
isozyme NOS1
Manually annotated by BRENDA team
-
NADPH-diaphorase is found in large and small neurons in the sensory, autonomic, and motor nuclei. In contrast to NADPH-diaphorase, nitric oxide synthase in the corresponding nuclei is always present in smaller quantities of mainly smaller neurons. In some nuclei (the nucleus ambiguus, the nucleus of the hypoglossal nerve) containing large numbers of NADPH-diaphorase-positive neurons, nitric oxide synthase immunoreactive cells are particularly rare
Manually annotated by BRENDA team
-
constitutive expression of full length nitric oxide synthase isoforms. Isolated monocytes express more endothelial nitric oxide synthase transcript and protein as compared to neuronal nitric oxide synthase and inducible nitric oxide synthase
Manually annotated by BRENDA team
-
three isoforms of nitric oxide synthase are mainly localized in the uterine luminal and glandular epithelium and myometrium, and the intensity of immunostaining for inducible nitric oxide synthase and endothelial nitric oxide synthase increases gradually with temporal development of the postnatal uterus. The total nitric oxide synthase and inducible nitric oxide synthase activities are significantly increased at postnatal days 21 and 35. Although constitutive nitric oxide synthase activity is increased at postnatal day 21, it decreases subsequently at postnatal day 35. Inducible nitric oxide synthase protein expression is significantly increased at postnatal days 21 and 35
Manually annotated by BRENDA team
-
type I neurons are generated during early corticogenesis, whereas type II cells are produced over a wide prenatal time window persisting until birth. Type II nitrinergic neurons may undergo a period of development/differentiation, for over 1 month, before being NADPH-diaphorase reactive
Manually annotated by BRENDA team
constitutive expression of Ca22+/calmodulin-dependent neuronal nitric oxide synthase in the central and peripheral nervous system
Manually annotated by BRENDA team
of central ganglia
Manually annotated by BRENDA team
-
constitutive expression of full length nitric oxide synthase isoforms with the highest expression of inducible nitric oxide synthase in comparison to neuronal nitric oxide synthase and endothelial nitric oxide synthase
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
n the skin, eNOS is present in the epidermal layer, hair follicles and also in the endothelial cells lining the blood vessels
Manually annotated by BRENDA team
-
distribution, overview, before and after axotomy and fibroblast growth factor-2 application
Manually annotated by BRENDA team
-
i.e. HUVEC cells
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
three isoforms of nitric oxide synthase are mainly localized in the uterine luminal and glandular epithelium and myometrium, and the intensity of immunostaining for inducible nitric oxide synthase and endothelial nitric oxide synthase increases gradually with temporal development of the postnatal uterus. The total nitric oxide synthase and inducible nitric oxide synthase activities are significantly increased at postnatal days 21 and 35. Although constitutive nitric oxide synthase activity is increased at postnatal day 21, it decreases subsequently at postnatal day 35. Inducible nitric oxide synthase protein expression is significantly increased at postnatal days 21 and 35
Manually annotated by BRENDA team
additional information