1.14.13.44: 2-hydroxybiphenyl 3-monooxygenase

This is an abbreviated version!
For detailed information about 2-hydroxybiphenyl 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.44

Reaction

2-Hydroxybiphenyl
+
NADH
+
H+
+
O2
=
2,3-Dihydroxybiphenyl
+
NAD+
+
H2O

Synonyms

2-hydroxybiphenyl 3-monooxygenase, HbpA, oxygenase, 2-hydroxybiphenyl 3-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.44 2-hydroxybiphenyl 3-monooxygenase

Reference

Reference on EC 1.14.13.44 - 2-hydroxybiphenyl 3-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meyer, A.; Schmid, A.; Held, M.; Westphal, A.H.; Rothlisberger, M.; Kohler, H.P.E.; Van Berkel, W.J.H.; Witholt, B.
Changing the substrate reactivity of 2-hydroxybiphenyl 3-monooxygenase from Pseudomonas azelaica HBP1 by directed evolution
J. Biol. Chem.
277
5575-5582
2002
Pseudomonas nitroreducens, Pseudomonas nitroreducens HBP1
Manually annotated by BRENDA team
Meyer, A.; Wursten, M.; Schmid, A.; Kohler, H.P.; Witholt, B.
Hydroxylation of indole by laboratory-evolved 2-hydroxybiphenyl 3-monooxygenase
J. Biol. Chem.
277
34161-34167
2002
Pseudomonas nitroreducens, Pseudomonas nitroreducens HBP1
Manually annotated by BRENDA team
Suske, W.A.; Van Berkel, W.J.H.; Kohler, H.P.E.
Catalytic mechanism of 2-hydroxybiphenyl 3-monooxygenase, a flavoprotein from Pseudomonas azelaica HBP1
J. Biol. Chem.
274
33355-33365
1999
Pseudomonas nitroreducens, Pseudomonas nitroreducens HBP1
Manually annotated by BRENDA team
Suske, W.A.; Held, M.; Schmid, A.; Fleischmann, T.; Wubbolts, M.G.; Kohler, H.P.E.
Purification and characterization of 2-hydroxybiphenyl 3-monooxygenase, a novel NADH-dependent, FAD-containing aromatic hydroxylase from Pseudomonas azelaica HBP1
J. Biol. Chem.
272
24257-24265
1997
Pseudomonas nitroreducens, Pseudomonas nitroreducens HBP1
Manually annotated by BRENDA team
Meyer, A.; Tanner, D.; Schmid, A.; Sargent, D.F.; Kohler, H.P.; Witholt, B.
Crystallization and preliminary X-ray analysis of native and selenomethionine 2-hydroxybiphenyl 3-monooxygenase
Acta Crystallogr. Sect. D
59
741-743
2003
Pseudomonas nitroreducens
Manually annotated by BRENDA team
Held, M.; Schmid, A.; Kohler, H.P.; Suske, W.; Witholt, B.; Wubbolts, M.
An integrated process for the production of toxic catechols from toxic phenols based on a designer biocatalyst
Biotechnol. Bioeng.
62
641-648
1999
Escherichia coli, Escherichia coli JM101
Manually annotated by BRENDA team
Kanteev, M.; Bregman-Cohen, A.; Deri, B.; Shahar, A.; Adir, N.; Fishman, A.
A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism
Biochim. Biophys. Acta
1854
1906-1913
2015
Pseudomonas nitroreducens (O06647)
Manually annotated by BRENDA team
Jensen, C.N.; Mielke, T.; Farrugia, J.E.; Frank, A.; Man, H.; Hart, S.; Turkenburg, J.P.; Grogan, G.
Structures of the Apo and FAD-bound forms of 2-hydroxybiphenyl 3-monooxygenase (HbpA) locate activity hotspots identified by using directed evolution
ChemBioChem
16
968-976
2015
Pseudomonas nitroreducens (O06647)
Manually annotated by BRENDA team