1.14.13.54: ketosteroid monooxygenase

This is an abbreviated version!
For detailed information about ketosteroid monooxygenase, go to the full flat file.

Reaction

Synonyms

17alpha-Hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), Androgen hydroxylase, Androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing), Baeyer-Villiger monooxygenase, BVMO, CYP106A2, Hydroxylase, steroid, NADPH-dependent steroid Baeyer-Villiger monooxygenase, Oxygenase, steroid mono-, Progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), Steroid hormone hydroxylase, Steroid hydroxylase, steroid hydroxylating cytochrome, Steroid monooxygenase, Steroid-ketone monooxygenase, STMO

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.54 ketosteroid monooxygenase

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Results	in table
1	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
5	Inhibitors
12	kcat/KM [mM/s]
16	KM Value [mM]
5	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
10	Organism
4	PDB ID
3	pH Optimum
2	pH Range
5	Protein Variants
3	Purification (Commentary)
4	Reaction
2	Reaction Type
8	Reference
1	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
1	Storage Stability
33	Substrates and Products (Substrate)
5	Subunits
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
6	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.13.54 - ketosteroid monooxygenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5-Pregnene-3beta,20alpha-diol

Ilyonectria destructans

-

lactonization of androstenedione

7389

pregnenolone

Ilyonectria destructans

-

and other C21-20-ketosteroids which are the substrates for oxygenative esterification of the enzyme, strongly inhibit lactonization of androstenedione

7389

progesterone

Ilyonectria destructans

-

strong, competitive inhibitor of lactonization of 17-ketosteroids

7389

testosterone

Ilyonectria destructans

-

lactonization of androstenedione

7389

Testosterone acetate

Ilyonectria destructans

-

lactonization of androstenedione

7389