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1.14.13.59: L-lysine N6-monooxygenase (NADPH)

This is an abbreviated version!
For detailed information about L-lysine N6-monooxygenase (NADPH), go to the full flat file.

Word Map on EC 1.14.13.59

Reaction

L-lysine
+
NADPH
 +
H+
 +
O2
=
N6-hydroxy-L-lysine
 +
NADP+
 +
H2O

Synonyms

EC 1.13.12.10, EC 13.12.10, flavin-dependent lysine monooxygenase, flavin-dependent N6-lysine monooxygenase, IucD, LH, lysine monooxygenase, Lysine N(6)-hydroxylase, Lysine N6-hydroxylase, lysine N6-monooxygenase, lysine: N6-hydroxylase, lysine:N(6)-hydroxylase, Lysine:N6-hydroxylase, MbsG, N-hydroxylating monooxygenase, NbtG, Oxygenase, lysine N6-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.59 L-lysine N6-monooxygenase (NADPH)

Inhibitors

Inhibitors on EC 1.14.13.59 - L-lysine N6-monooxygenase (NADPH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Carbonylcyanide-m-chlorophenylhydrazone
-
-
Carbonylcyanide-p-fluoromethoxyphenylhydrazone
-
-
Cinnamylidene
-
-
Cl-
-
above 600 mM, enzyme exists in a reversible inactive conformation
FAD
-
inhibition of the wild-type and mutant P14G enzymes at very high concentrations
FAD analogs
-
complete loss of activity after prolonged incubation with 8-chloro-FAD, 8-fluoro-FAD, 8-mercapto-FAD or 8-methoxy-FAD
-
L-lysine
-
substrate inhibition of the wild-type and mutant P14G enzymes
p-chloromercuribenzoate
-
0.01 mM, 62% inhibition, reversed by dithiothreitol
additional information
-