1.14.13.71: N-methylcoclaurine 3'-monooxygenase

This is an abbreviated version!
For detailed information about N-methylcoclaurine 3'-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.71

transferred to EC 1.14.14.102


Synonyms

(S)-N-methylcoclaurine-3-hydroxylase, CYP80B, LOC104585940, N-methylcoclaurine 3'-hydroxylase, NMCH

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.71 N-methylcoclaurine 3'-monooxygenase

General Information

General Information on EC 1.14.13.71 - N-methylcoclaurine 3'-monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme is involved in the common pathway of benzylisoquinoline alkaloid biosynthesis and the aporphine alkaloid bisynthesis pathway in lotus, overview. A series of enzymes, norcoclaurine 6-O-methyltransferase (6OMT), coclaurineN-methyltransferase (CNMT), (S)-N-methylcoclaurine-3-hydroxylase (NMCH), and 3-hydroxy-N-methylcoclaurine 4'-O-methyltransferase(4'OMT), exhibit catalytic activity to yield the central branchpoint intermediate (S)-reticuline
physiological function
the expression of isozyme 1 is low in the two cultivars, so it may have little effect on alkaloid contents. The expression of CYP80B, NNU08355, has a positive effect on aporphine alkaloids content in lotus, but exhibits phenotypic lag, which might be because of NMCH which acts early in the benzylisoquinoline alkaloid biosynthetic pathway