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1.14.13.8: flavin-containing monooxygenase

This is an abbreviated version!
For detailed information about flavin-containing monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.8

Reaction

Hypotaurine
+
H2O
+
NAD+
=
taurine
+
NADH
+
H+

Synonyms

class 3 flavin-containing mono-oxygenase, class 3 FMO, dechlorinating flavin-dependent monooxygenase, dimethylaniline monooxygenase (N-oxide-forming), dimethylaniline monooxygenase [N-oxide-forming] 1, dimethylaniline N-oxidase, dimethylaniline oxidase, dimethylsulfone monooxygenase, DMA oxidase, EC 1.13.12.11, EC 1.8.1.3, EtaA, FAD-containing monooxygenase, FAD-containing monooxygenase 3, flavin containing monooxygenase 3, flavin mono-oxygenase, flavin monooxygenase, flavin-containing mono-oxygenase, flavin-containing monooxygenase, flavin-containing monooxygenase 1, flavin-containing monooxygenase 3, flavin-containing monooxygenase 5, flavin-containing monooxygenase-3, flavin-containing-monooxygenase, flavin-dependent monooxygenase, flavoprotein monooxygenase, FMO, FMO 1A1, FMO 1B1, FMO 1C1, FMO 1D1, FMO 1E1, FMO-E, FMO-I, FMO-II, FMO1, FMO2, FMO2.1, FMO3, FMO4, FMO5, FMOGS-OX6, FMOGS-OX7, HadA, hFMO1, hFMO3, hFMO5, Met S-oxidase, mFMO, mixed-function amine oxidase, monooxygenase FMO1, More, MymA, N,N-dimethylaniline monooxygenase, oxygenase, dimethylaniline mono- (N-oxide-forming), oxygenase, methylphenyltetrahydropyridine N-mono-, PtFMO, sfnG, TetX, type II flavin-containing monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.8 flavin-containing monooxygenase

Cloned

Cloned on EC 1.14.13.8 - flavin-containing monooxygenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA data
cDNA from liver, DNA and amino acid sequence determination and analysis, genomic structure and sequence comparison, expression analysis
DNA and amino acid sequence determination and analysis of multiple samples of gene FMO3, expression of clones in Spodoptera frugiperda Sf9 insect cell microsomes via baculovirus transfection system, the FMO multigene family consists of a five-gene cluster at 1q24.3, comprising FMO1-4 and FMO6p, and a second cluster of five genes at 1q24.2, comprising FMO7p-11p, and a single gene, FMO5, at 1q21.1, encoding a total of five active proteins in humans
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DNA sequence determination and analysis, and genotyping
expressed in Escherichia coli
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expressed in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli JM109 cells
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expressed in Escherichia coli Top10 cells
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expressed in Sf9 insect cell microsomes
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expressed in Sf9 insect cells
expressed in Trichoplusia ni cells using a baculovirus expression vector system
expression analysis of FMO3 in liver and after treatment with conjugated linoleic acid isomers
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expression as maltose-binding fusion proteins in Escherichia coli
expression in Escherichia coli
expression in yeast cells
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expression of FMO1, FMO2.1, and FMO3 in Spodoptera frugiperda Sf9 cell microsomes
expression of FMO3 and FMO5 as N-terminal maltose-binding protein fusion proteins, MBP-FMOs, in Escherichia coli strain DH5alpha
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expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
expression of His-tagged EtaA in Escherichia coli strain DH5alpha
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expression of isozyme FMO genetic variants in Spodoptera frugiperda Sf9 insect cell microsomes via baculovirus transfection system
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expression of isozymes FMO1-FMO5, optimized for heterologous expression, in Escherichia coli, isozymes FMO1-FMO4 are active with peptide-bound methionine, while FMO5 is inactive
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expression of maltose-binding protein fusion enzymes FMO1, FMO3, and FMO5 in Escherichia coli
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expression of N-terminally His6-tagged truncation mutant in Escherichia coli as soluble enzyme, and expression of the mutant in Spodoptera frugiperda Sf9 insect cells
expression of wild-type and mutant FMO3 in Escherichia coli strain JM109
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expression of wild-type and mutant isozymes FMO1 and FMO3 as N-terminally maltose-binding-protein fusion and C-terminally His6-tagged proteins in Escherichia coli strain JM109
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expression of wild-type enzyme and mutants M66I and R492W in Spodoptera frugiperda Sf9 cell membranes
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five genes encoding isozymes FMO1-FMO5 and 1 pseudogene organized in a gene cluster
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FMO isozyme expression patterns, expression analysis
FMO, DNA and amino acid sequence determination and analysis, sequence comparison, expression in Escherichia coli strain BL21 (DE3)
FMO1, DNA and amino acid sequence determination and analysis, phylogenetic analysis
FMO2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
FMO3 cDNA from liver, DNA and amino acid sequence determination and analysis, expression in Spodoptera frugiperda Sf9 insect cells
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FMO3 cDNA from liver, expression in Spodoptera frugiperda Sf9 insect cells
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FMO3, DNA and amino acid sequence determination and analysis, genotyping
FMO3, DNA and amino acid sequence determination and analysis, the gene maps to the long arm of chromosome 1, phylogenetic analysis
FMO3, genotyping in relation to gender, age, race/ethnic, and FMO3 expression in response to administration of the anti-schizophrenia drug olanzapine
FMO4, DNA and amino acid sequence determination and analysis, phylogenetic analysis, the gene maps to the long arm of chromosome 1, genotyping and alternative splicing variants, overview
FMO5, the gene encoding the enzyme is located at 1q21.1, not in the FMO gene cluster at 1q24.3, DNA and amino acid sequence determination and analysis, phylogenetic analysis
functional expression of isozymes FMO1-FMO3, in Escherichia coli
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gene FMO1, DNA and amino acid sequence determination and analysis, the gene contains five long interspersed nuclear element-1-like elements, i.e. LINE elements, expression analysis, silencing of FMO1 in adult human liver is due apparently to the presence upstream of the proximal P0 of LINE-1 elements rather than the absence of retrotransposons, expression in Hep-G2 cells
gene FMO1, DNA and amino acid sequence determination and analysis, the gene contains polyA region, an 80 bp direct repeat, an long terminal, LTR, repeat, a short-interspersed nuclear element, i.e. SINE element, and a poly T tract, expression analysis, expression in Hep-G2 cells
gene FMO1, genes FMO1 to FMO4 are clustered on chromosome 1 at q24.3, along with a pseudogene FMO6P
gene FMO2, genes FMO1 to FMO4 are clustered on chromosome 1 at q24.3, along with a pseudogene FMO6P
gene fMO3, DNA and amino acid sequence determination and analysis of wild-type and natural mutant enzymes, overview
gene FMO3, DNA and amino acid sequence determination and analysis, transient expression in Hep-G2 cells
gene FMO3, genes FMO1 to FMO4 are clustered on chromosome 1 at q24.3, along with a pseudogene FMO6P
gene FMO3, recombinant expression of C-terminally His-tagged wild-type and mutant enzymes in Escherichia coli
gene FMO3, recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain JM109
gene Fmo5, FMO5 is located at 1q21.1 on chromosome 5, quantitative enzyme expression analysis
gene tetX, expression in Escherichia coli confers antibiotic resistance
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genes fmo1, fmo2, fmo3, quantitative expression analysis in different tissues, expression in Spodoptera frugiperda Sf9 cells using the baculovirus transfection system
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genes FMO1-FMO6, FMO6 is a pseudogene, the genes are organized in two clusters chromosome 1, one of which resides on the long arm of chromosome 1 at q23 –25, the second cluster is composed of 3 genes, that are not pseudogenes
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genes FMO1-FMO6, FMO6 is a pseudogene, the genes are organized in two clusters chromosome 1, one of which resides on the long arm of chromosome 1 at q23 –25, the second cluster is composed of 5 pseudogenes
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independent expression of isozymes FMO1 and FMO3 in Spodoptera frugiperda Sf9 insect cell microsomes via baculovirus transfection system
missense mutations causing fish-odour syndrome
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overexpression of PTDH-mFMO fusion protein in Escherichia coli
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overexpression of the FMO1 cDNA under control of the 35S CaMV promoter in independent transgenic Col-0 lines
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quantitative Fmo isozyme expression analysis in female C3H/HeOuJ and C57BL/6 mice
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recombinant expression of enzyme PtFMO in Escherichia coli in presence of tryptophan leading to formation of indigo, coexpression of PtFMO with indoxyl beta-D-glucoside synthase (PtIGS), which catalyzes the glucosylation of indoxyl, brings about the formation of indican
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recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain JM109
recombinant expression of His-tagged wild-type and mutant full-length and truncated enzyme variants in Escherichia coli strain JM109
using a baculovuirus expression system in Sf-9 insect cells, dFMO1 is expressed to protein levels of 0.4 nM/mg
whole genome microarrays to examine the EDS1 regulatory node in disease resistance and correlation of FMO1 expression, overview