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1.14.13.9: kynurenine 3-monooxygenase

This is an abbreviated version!
For detailed information about kynurenine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.9

Reaction

L-kynurenine
+
NADPH
 +
H+
 +
O2
=
3-hydroxy-L-kynurenine
 +
NADP+
 +
H2O

Synonyms

BcKMO, Bna4, cinnabar, EC 1.14.1.2, EC 1.99.1.5, FAD dependent kynurenine 3-monooxygenase, flavin adenine dinucleotide dependent kynurenine 3-monooxygenase, hKMO, Hs-KMO, K3H, KMO, KYN-OHase, kynurenine 3-hydroxylase, kynurenine 3-monooxygenase, kynurenine hydroxylase, kynurenine monooxygenase, kynurenine-3-monooxygenase, L-kynurenine 3-monooxygenase, L-kynurenine,NADPH2:oxygen oxidoreductase (3-hydroxylating), L-kynurenine-3-hydroxylase, More, NADPH-dependent flavin monooxygenase, oxygenase, kynurenine 3-mono-, pfKMO, Rat-KMO, scKMO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.9 kynurenine 3-monooxygenase

KI Value

KI Value on EC 1.14.13.9 - kynurenine 3-monooxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000095
(R,S)-2-amino-oxo-4-(3'-4'-dichlorophenyl)butanoic acid
-
competitive inhibitor
0.034
3,4-dichlorohippuric acid
pH and temperature not specified in the publication
0.0000048
3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide
-
competitive inhibitor
0.033 - 1
3,4-dimethoxyhippuric acid
0.0015
3,5-dibromo-L-kynurenine
pH and temperature not specified in the publication
0.0138
3-chloro-DL-kynurenine
pH and temperature not specified in the publication
0.0086
3-methyl-DL-kynurenine
pH and temperature not specified in the publication
0.011
5-bromo-3-chloro-DL-kynurenine
pH and temperature not specified in the publication
0.0102
5-bromo-3-methyl-DL-kynurenine
pH and temperature not specified in the publication
4.2 - 8.3
alpha-Ketoisocaproate
11.2 - 24.5
chloride
1
pyridoxal
-
-
0.17 - 0.27
pyridoxal 5'-phosphate
0.0135
Ro 61-8048
pH and temperature not specified in the publication