1.14.13.9: kynurenine 3-monooxygenase
This is an abbreviated version!
For detailed information about kynurenine 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.9
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1.14.13.9
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mercury
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hg
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kynurenic
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3-hydroxykynurenine
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quinolinic
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2,3-dioxygenase
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kynureninase
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indoleamine
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cronbach
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huntington
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bartlett
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paint
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3-hydroxyanthranilic
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quin
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neuroactive
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ochre
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realgar
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psychometric
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calcite
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methylmercury
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xanthurenic
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eigenvalue
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vermilion
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hematite
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test-retest
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excitotoxins
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ommochrome
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artwork
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geochemical
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indoleamine-2,3-dioxygenase
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archaeological
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varimax
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roman
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mineralogical
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slovenia
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micro-raman
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molecular biology
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medicine
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analysis
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pharmacology
- 1.14.13.9
- mercury
- hg
-
kynurenic
- 3-hydroxykynurenine
-
quinolinic
-
2,3-dioxygenase
- kynureninase
- indoleamine
-
cronbach
- huntington
-
bartlett
-
paint
-
3-hydroxyanthranilic
-
quin
-
neuroactive
-
ochre
-
realgar
-
psychometric
-
calcite
- methylmercury
-
xanthurenic
-
eigenvalue
-
vermilion
-
hematite
-
test-retest
-
excitotoxins
-
ommochrome
-
artwork
-
geochemical
- indoleamine-2,3-dioxygenase
-
archaeological
-
varimax
-
roman
-
mineralogical
-
slovenia
-
micro-raman
- molecular biology
- medicine
- analysis
- pharmacology
Reaction
Synonyms
BcKMO, Bna4, cinnabar, EC 1.14.1.2, EC 1.99.1.5, FAD dependent kynurenine 3-monooxygenase, flavin adenine dinucleotide dependent kynurenine 3-monooxygenase, hKMO, Hs-KMO, K3H, KMO, KYN-OHase, kynurenine 3-hydroxylase, kynurenine 3-monooxygenase, kynurenine hydroxylase, kynurenine monooxygenase, kynurenine-3-monooxygenase, L-kynurenine 3-monooxygenase, L-kynurenine,NADPH2:oxygen oxidoreductase (3-hydroxylating), L-kynurenine-3-hydroxylase, More, NADPH-dependent flavin monooxygenase, oxygenase, kynurenine 3-mono-, pfKMO, Rat-KMO, scKMO
ECTree
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Reference on EC 1.14.13.9 - kynurenine 3-monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okamoto, H.; Hayaishi, O.
Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria
Biochem. Biophys. Res. Commun.
29
394-399
1967
Rattus norvegicus
Saito, Y.; Hayaishi, O.; Rothenberg, S.
Studies on oxygenases: Enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine
J. Biol. Chem.
229
921-934
1957
Rattus norvegicus, Rattus norvegicus Osborne-Mendel
Nisimoto, Y.; Takeuchi, F.; Shibata, Y.
Molecular properties of L-kynurenine 3-hydroxylase from rat liver mitochondria
J. Biochem.
81
1413-1425
1977
Rattus norvegicus
Nisimoto, Y.; Takeuchi, F.; Shibata, Y.
Isolation of L-kynurenine 3-hydroxylase from the mitochondrial outer membrane of rat liver
J. Biochem.
78
573-581
1975
Rattus norvegicus
Nishimoto, Y.; Takeuchi, F.; Shibata, Y.
Purification of L-kynurenine 3-hydroxylase by affinity chromatography
J. Chromatogr.
169
357-364
1979
Rattus norvegicus
McLean-Bowen, C.A.; Parks, L.W.
Corresponding changes in kynurenine hydroxylase activity, membrane fluidity, and sterol composition in Saccharomyces cerevisiae mitochondria
J. Bacteriol.
145
1325-1333
1981
Saccharomyces cerevisiae
Schott, H.H.; Staudinger, H.
The regulatory function of L-kynurenine 3-hydroxylase (EC 1.14.1.2) for the biosynthesis of pyridine nucleotides in anaerobically and aerobically grown Saccharomyces cerevisiae
Hoppe-Seyler's Z. Physiol. Chem.
352
1654-1658
1971
Saccharomyces cerevisiae
Saito, K.; Quearry, B.J.; Saito, M.; Nowak, T.S.Jr.; Markey S.P.; Heyes, M.P.
Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia
Arch. Biochem. Biophys.
307
104-109
1993
Meriones unguiculatus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
Pinamonti, S.; Chiarelli-Alvisi, G.
Kynurenine-3-hydroxylase of Schistocera gregaria
Insect Biochem.
4
9-16
1974
Schistocerca gregaria
-
Stratakis, E.
Subcellular localization and properties of kynurenine 3-hydroxylase from eggs of Ephestia kuhniella Z
J. Comp. Physiol.
141
451-456
1981
Ephestia kuehniella
-
Shin, M.; Sano, K.; Umezawa, C.
Inhibition of L-kynurenine 3-hydroxylase from Saccharomyces carlsbergensis by alpha-keto acid derivatives of branched chain amino acids
J. Nutr. Sci. Vitaminol.
28
191-201
1982
Saccharomyces pastorianus
Giordani A.; Pevarello P.; Cini, M.; Bormetti, R.; Greco, F.; Toma, S.; Speciale, C.; Varasi, M.
4-phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase
Bioorg. Med. Chem. Lett.
8
2907-2012
1998
Rattus norvegicus
Speciale, C.; Cini, M.; Wu, H.Q.; Salvati, P.; Schwarcz, R.; Molinari, A.; Calabresi, M.; Varasi, M.
Kynurenic acid-enhancing and anti-ischemic effects of the potent kynurenine 3-hydroxylase inhibitor FCE28833 in rodents
Adv. Exp. Med. Biol.
398
221-227
1996
Rattus norvegicus
Rover, S.; Cesura, A.M.; Huguenin, P.; Kettler, R.; Szente, A.
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase
J. Med. Chem.
40
4378-4385
1997
Rattus norvegicus
Uemura, T.; Hirai, K.
Purification of L-kynurenine 3-monooxygenase from mitochondrial outer membrane of pig liver
Adv. Exp. Med. Biol.
467
619-623
1999
Sus scrofa
Cozzi, A.; Carpenedo, R.; Moroni, F.
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia
J. Cereb. Blood Flow Metab.
19
771-777
1999
Meriones unguiculatus, Rattus norvegicus
Heidempergher, F.; Pevarello, P.; Pillan, A.; Pinciroli, V.; Torre, A.D.; Speciale, C.; Marconi, M.; Cini, M.; Toma, S.; Greco, F.; Varasi, M.
Pyrrolo[3,2-c]quinoline derivates: a new class of kynurenine-3-hydroxylase inhibitors
Farmaco
54
152-160
1999
Rattus norvegicus
Breton, J.; Avanzi, N.; Magagnin, S.; Covini, N.; Magistrelli, G.; Cozzi, L.; Isacchi, A.
Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase
Eur. J. Biochem.
267
1092-1099
2000
Rattus norvegicus
Chiarugi, A.; Cozzi, A.; Massacesik L.; Moroni, F.
Kynurenine 3-momo-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis
Neuroscience
102
687-695
2001
Rattus norvegicus
Drysdale, M.J.; Hind, S.L.; Jansen, M.; Reinhard, J.F.Jr
Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents
J. Med. Chem.
43
123-127
2000
Homo sapiens
Urenjak, J.; Obrenowitch, T.P.
Kynurenine 3-hydroxylase inhibition in rats: Effects on extracellular kynurenic acid concentration and N-methyl-D-aspartate-induced depolarisation in the striatum
J. Neurochem.
75
2427-2433
2000
Rattus norvegicus
Alberati-Giani, D.; Cesuura, A.M.; Broger, C.; Warren, W.D.; Rover, S.; Malherbe, P.
Cloning and functional expression of human kynurenine 3-monooxygenase
FEBS Lett.
410
407-412
1997
Homo sapiens
Pellicciari, R.; Natalini, B.; Costantino, G.; Mahmoud, M.R.; Mattoli, L.; Sadeghpour, B.M.; Moroni, F.; Chiarugi, A.; Carpenedo, R.
Modulation of the kynurenine pathway in search for new neruoprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoys)alanine, a potent inhibitor of kynurenine-3-hydroxylase
J. Med. Chem.
37
647-655
1994
Rattus norvegicus
Allegri, G.; Bertazzo, A.; Biasiolo, M.; Costa, C.V.; Ragazzi, E.
Kynurenine pathway enzymes in different species of animals
Adv. Exp. Med. Biol.
527
455-463
2003
Cavia porcellus, Oryctolagus cuniculus, Mus musculus, Rattus norvegicus
Lorenzen, M.D.; Brown, S.J.; Denell, R.E.; Beeman, R.W.
Cloning and characterization of the Tribolium castaneum eye-color genes encoding tryptophan oxygenase and kynurenine 3-monooxygenase
Genetics
160
225-234
2002
Drosophila melanogaster (A1Z745), Tribolium castaneum (Q95NP6), Tribolium castaneum
Hirai, M.; Kiuchi, M.; Wang, J.; Ishii, A.; Matsuoka, H.
cDNA cloning, functional expression and characterization of kynurenine 3-hydroxylase of Anopheles stephensi (Diptera: Culicidae)
Insect Mol. Biol.
11
497-504
2002
Anopheles stephensi (Q8ISJ5), Anopheles stephensi
Han, Q.; Calvo, E.; Marinotti, O.; Fang, J.; Rizzi, M.; James, A.A.; Li, J.
Analysis of the wild-type and mutant genes encoding the enzyme kynurenine monooxygenase of the yellow fever mosquito, Aedes aegypti
Insect Mol. Biol.
12
483-490
2003
Aedes aegypti (Q86PM2), Aedes aegypti, Aedes aegypti Liverpool (Q86PM2)
Giorgini, F.; Guidetti, P.; Nguyen, Q.; Bennett, S.C.; Muchowski, P.J.
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease
Nat. Genet.
37
526-531
2005
Saccharomyces cerevisiae, Homo sapiens
Ligam, P.; Manuelpillai, U.; Wallace, E.M.; Walker, D.
Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy
Placenta
26
498-504
2005
Homo sapiens
Comai, S.; Costa, C.V.; Ragazzi, E.; Bertazzo, A.; Allegri, G.
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats
Clin. Chim. Acta
360
67-80
2005
Rattus norvegicus
Ceresoli-Borroni, G.; Guidetti, P.; Amori, L.; Pellicciari, R.; Schwarcz, R.
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications
J. Neurosci. Res.
85
845-854
2007
Mus musculus, Rattus norvegicus
Ragazzi, E.; Costa, C.V.; Comai, S.; Bertazzo, A.; Caparrotta, L.; Allegri, G.
Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits
Life Sci.
78
785-794
2006
Oryctolagus cuniculus
Crozier, K.R.; Moran, G.R.
Heterologous expression and purification of kynurenine-3-monooxygenase from Pseudomonas fluorescens strain 17400
Protein Expr. Purif.
51
324-333
2007
Pseudomonas fluorescens, Pseudomonas fluorescens 17400
Gregoire, L.; Rassoulpour, A.; Guidetti, P.; Samadi, P.; Bedard, P.J.; Izzo, E.; Schwarcz, R.; Di Paolo, T.
Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in Parkinsonian monkeys
Behav. Brain Res.
186
161-167
2008
Macaca fascicularis
Quan, G.; Kobayashi, I.; Kojima, K.; Uchino, K.; Kanda, T.; Sezutsu, H.; Shimada, T.; Tamura, T.
Rescue of white egg 1 mutant by introduction of the wild-type Bombyx kynurenine 3-monooxygenase gene
Insect Sci.
14
85-92
2007
Bombyx mori, Bombyx mori (Q95NK3), Bombyx mori C108
-
Connor, T.J.; Starr, N.; OSullivan, J.B.; Harkin, A.
Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?
Neurosci. Lett.
441
29-34
2008
Rattus norvegicus
Crozier-Reabe, K.R.; Phillips, R.S.; Moran, G.R.
Kynurenine 3-monooxygenase from Pseudomonas fluorescens: substrate-like inhibitors both stimulate flavin reduction and stabilize the flavin-peroxo intermediate yet result in the production of hydrogen peroxide
Biochemistry
47
12420-12433
2008
Pseudomonas fluorescens
Amori, L.; Guidetti, P.; Pellicciari, R.; Kajii, Y.; Schwarcz, R.
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo
J. Neurochem.
109
316-325
2009
Rattus norvegicus
Hirai, K.; Kuroyanagi, H.; Tatebayashi, Y.; Hayashi, Y.; Hirabayashi-Takahashi, K.; Saito, K.; Haga, S.; Uemura, T.; Izumi, S.
Dual role of the carboxyl-terminal region of pig liver L-kynurenine 3-monooxygenase: mitochondrial-targeting signal and enzymatic activity
J. Biochem.
148
639-650
2010
Sus scrofa (Q9MZS9), Sus scrofa
Stephens, G.L.; Wang, Q.; Swerdlow, B.; Bhat, G.; Kolbeck, R.; Fung, M.
Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands
Eur. J. Immunol.
43
1727-1734
2013
Mus musculus
Winkler, D.; Beconi, M.; Toledo-Sherman, L.M.; Prime, M.; Ebneth, A.; Dominguez, C.; Munoz-Sanjuan, I.
Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO)
J. Biomol. Screen.
18
879-889
2013
Homo sapiens
Amaral, M.; Levy, C.; Heyes, D.J.; Lafite, P.; Outeiro, T.F.; Giorgini, F.; Leys, D.; Scrutton, N.S.
Structural basis of kynurenine 3-monooxygenase inhibition
Nature
496
382-385
2013
Saccharomyces cerevisiae (P38169), Saccharomyces cerevisiae
Tashiro, T.; Murakami, Y.; Mouri, A.; Imamura, Y.; Nabeshima, T.; Yamamoto, Y.; Saito, K.
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions
Behav. Brain Res.
317
279-285
2017
Mus musculus (Q91WN4)
Erhardt, S.; Pocivavsek, A.; Repici, M.; Liu, X.C.; Imbeault, S.; Maddison, D.C.; Thomas, M.A.R.; Smalley, J.L.; Larsson, M.K.; Muchowski, P.J.; Giorgini, F.; Schwarcz, R.
Adaptive and behavioral changes in kynurenine 3-monooxygenase knockout mice relevance to psychotic disorders
Biol. Psychiatry
82
756-765
2017
Mus musculus (Q91WN4), Mus musculus
Phillips, R.S.; Anderson, A.D.; Gentry, H.G.; Guener, O.F.; Bowen, J.P.
Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii
Bioorg. Med. Chem. Lett.
27
1705-1708
2017
Cytophaga hutchinsonii (Q11PP7), Cytophaga hutchinsonii
Liddle, J.; Beaufils, B.; Binnie, M.; Bouillot, A.; Denis, A.A.; Hann, M.M.; Haslam, C.P.; Holmes, D.S.; Hutchinson, J.P.; Kranz, M.; McBride, A.; Mirguet, O.; Mole, D.J.; Mowat, C.G.; Pal, S.; Rowland, P.; Trottet, L.; Uings, I.J.; Walker, A.L.; Webster, S.P.
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis
Bioorg. Med. Chem. Lett.
27
2023-2028
2017
Homo sapiens (O15229)
Smith, J.R.; Jamie, J.F.; Guillemin, G.J.
Kynurenine-3-monooxygenase a review of structure, mechanism, and inhibitors
Drug Discov. Today
21
315-324
2016
Homo sapiens (O15229), Rattus norvegicus (O88867), Pseudomonas fluorescens (Q84HF5), Sus scrofa (Q9MZS9)
Gao, J.; Yao, L.; Xia, T.; Liao, X.; Zhu, D.; Xiang, Y.
Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048
FASEB J.
32
2036-2045
2017
Homo sapiens (O15229), Homo sapiens, Pseudomonas fluorescens (Q84HF5), Pseudomonas fluorescens
Quan, G.; Kobayashi, I.; Kojima, K.; Uchino, K.; Kanda, T.; Sezutsu, H.; Shimada, T.; Tamura, T.
Rescue of white egg 1 mutant by introduction of the wild-type Bombyx kynurenine 3-monooxygenase gene
Insect Sci.
14
85-92
2007
Bombyx mori (Q95NK3)
-
Walker, A.L.; Ancellin, N.; Beaufils, B.; Bergeal, M.; Binnie, M.; Bouillot, A.; Clapham, D.; Denis, A.; Haslam, C.P.; Holmes, D.S.; Hutchinson, J.P.; Liddle, J.; McBride, A.; Mirguet, O.; Mowat, C.G.; Rowland, P.; Tiberghien, N.; Trottet, L.; Uings, I.; Webster, S.P.; Zheng, X.; Mole, D.J.
Development of a series of kynurenine 3-monooxygenase inhibitors leading to a clinical candidate for the treatment of acute pancreatitis
J. Med. Chem.
60
3383-3404
2017
Pseudomonas fluorescens (Q84HF5)
Hutchinson, J.P.; Rowland, P.; Taylor, M.R.D.; Christodoulou, E.M.; Haslam, C.; Hobbs, C.I.; Holmes, D.S.; Homes, P.; Liddle, J.; Mole, D.J.; Uings, I.; Walker, A.L.; Webster, S.P.; Mowat, C.G.; Chung, C.W.
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
Nat. Commun.
8
15827
2017
Homo sapiens (O15229), Pseudomonas fluorescens (Q84HF5)
Gonzalez Esquivel, D.; Ramirez-Ortega, D.; Pineda, B.; Castro, N.; Rios, C.; Perez de la Cruz, V.
Kynurenine pathway metabolites and enzymes involved in redox reactions
Neuropharmacology
112
331-345
2017
Homo sapiens (O15229), Rattus norvegicus (O88867)
Wilson, K.; Mole, D.; Binnie, M.; Homer, N.; Zheng, X.; Yard, B.; Iredale, J.; Auer, M.; Webster, S.
Bacterial expression of human kynurenine 3-monooxygenase Solubility, activity, purification
Protein Expr. Purif.
95
96-103
2014
Homo sapiens (O15229), Homo sapiens
Sathyasaikumar, K.V.; Perez de la Cruz, V.; Pineda, B.; Vazquez Cervantes, G.I.; Ramirez Ortega, D.; Donley, D.W.; Severson, P.L.; West, B.L.; Giorgini, F.; Fox, J.H.; Schwarcz, R.
Cellular localization of kynurenine 3-monooxygenase in the brain challenging the dogma
Antioxidants (Basel)
11
0000
2022
Homo sapiens (A0A024R3S9), Mus musculus (Q91WN4)
Beaupre, B.A.; Reabe, K.R.; Roman, J.V.; Moran, G.R.
Hydrogen movements in the oxidative half-reaction of kynurenine 3-monooxygenase from Pseudomonas fluorescens reveal the mechanism of hydroxylation
Arch. Biochem. Biophys.
690
108474
2020
Pseudomonas fluorescens (Q84HF5), Pseudomonas fluorescens
Zhang, S.; Collier, M.E.W.; Heyes, D.J.; Giorgini, F.; Scrutton, N.S.
Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases
Arch. Biochem. Biophys.
697
108702
2021
Homo sapiens (A0A024R3S9), Rattus norvegicus (O88867), Mus musculus (Q91WN4)
Kimura, H.; Suda, H.; Kassai, M.; Endo, M.; Deai, Y.; Yahata, M.; Miyajima, M.; Isobe, Y.
N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors
Bioorg. Med. Chem. Lett.
33
127753
2021
Mus musculus (Q91WN4), Mus musculus R6/2 (Q91WN4)
Tsuboi, K.; Kimura, H.; Nakatsuji, Y.; Kassai, M.; Deai, Y.; Isobe, Y.
Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor
Bioorg. Med. Chem. Lett.
44
128115
2021
Homo sapiens (O15229), Mus musculus (Q91WN4), Mus musculus
Mimasu, S.; Yamagishi, H.; Kubo, S.; Kiyohara, M.; Matsuda, T.; Yahata, T.; Thomson, H.A.; Hupp, C.D.; Liu, J.; Okuda, T.; Kakefuda, K.
Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition
Commun. Biol.
4
159
2021
Homo sapiens (O15229), Rattus norvegicus (O88867)
Zheng, X.; Zhang, A.; Binnie, M.; McGuire, K.; Webster, S.P.; Hughes, J.; Howie, S.E.M.; Mole, D.J.
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury
Exp. Mol. Med.
51
1-14
2019
Mus musculus (Q91WN4), Mus musculus C57BL/6N x C57BL/6J (Q91WN4)
Lu, Y.; Shao, M.; Wu, T.
Kynurenine-3-monooxygenase a new direction for the treatment in different diseases
Food Sci. Nutr.
8
711-719
2020
Homo sapiens (O15229)
Lassiter, R.; Merchen, T.D.; Fang, X.; Wang, Y.
Protective role of kynurenine 3-monooxygenase in allograft rejection and tubular injury in kidney transplantation
Front. Immunol.
12
671025
2021
Homo sapiens (O15229), Sus scrofa (Q9MZS9), Sus scrofa
Zhang, K.; Yuan, X.; Zang, J.; Wang, M.; Zhao, F.; Li, P.; Cao, H.; Han, J.; Xing, J.; Dong, J.
The kynurenine 3-monooxygenase encoding gene, BcKMO, is involved in the growth, development, and pathogenicity of Botrytis cinerea
Front. Microbiol.
9
1039
2018
Botrytis cinerea, Botrytis cinerea BC22
Oezkilic, Y.; Tuezuen, N.S.
In silico methods predict new blood-brain barrier permeable structure for the inhibition of kynurenine 3-monooxygenase
J. Mol. Graph. Model.
100
107701
2020
Homo sapiens (O15229), Saccharomyces cerevisiae (P38169), Pseudomonas fluorescens (Q84HF5)
Oezkilic, Y.; Tuezuen, N.S.
Mechanism of kynurenine 3-monooxygenase-catalyzed hydroxylation reaction a quantum cluster approach
J. Phys. Chem. A
123
3149-3159
2019
Pseudomonas fluorescens (Q84HF5)
Hughes, T.D.; Guener, O.F.; Iradukunda, E.C.; Phillips, R.S.; Bowen, J.P.
The kynurenine pathway and kynurenine 3-monooxygenase inhibitors
Molecules
27
273
2022
Homo sapiens (O15229), Saccharomyces cerevisiae (P38169), Pseudomonas fluorescens (Q84HF5), Mus musculus (Q91WN4)
Morita, N.; Hoshi, M.; Hara, T.; Ninomiya, S.; Enoki, T.; Yoneda, M.; Tsurumi, H.; Saito, K.
Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity
Oncol. Lett.
22
790
2021
Homo sapiens (O15229)
Maddison, D.C.; Alfonso-Nunez, M.; Swaih, A.M.; Breda, C.; Campesan, S.; Allcock, N.; Straatman-Iwanowska, A.; Kyriacou, C.P.; Giorgini, F.
A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics
PLoS Genet.
16
e1009129
2020
Drosophila melanogaster (A1Z746), Drosophila melanogaster, Drosophila melanogaster Canton S (A1Z746)
Zhao, J.; Chen, J.; Wang, C.; Liu, Y.; Li, M.; Li, Y.; Li, R.; Han, Z.; Wang, J.; Chen, L.; Shu, Y.; Cheng, G.; Sun, C.
Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/IRF3-mediated IFN-beta production
PLoS Pathog.
18
e1010366
2022
Mus musculus (Q91WN4)
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