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1.14.14.16: steroid 21-monooxygenase

This is an abbreviated version!
For detailed information about steroid 21-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.16

Reaction

a C21 steroid
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
a 21-hydroxy-C21-steroid
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

17alpha-hydroxyprogesterone 21-hydrolase, 21-hydroxylase, 21-hydroxylase cytochrome P-450, 21OH, C3B21RA protein, CYP21, CYP21A2, CYP2D, Cytochrome P-450 specific for steroid C-21 hydroxylation, cytochrome P-450-linked mixed function oxidase system, cytochrome P-450C-21, cytochrome p450 21A2, cytochrome P450 steroid 21-hydroxylase, cytochrome P450c21, EC 1.14.1.8, EC 1.14.99.10, EC 1.99.1.11, P-450(C21), P450 oxidoreductase-21-hydroxylase, P450-C21, P450-C21B, P450c21, Progesterone 21-hydroxylase, Steroid 21-hydroxylase, steroid 21-hydroxylase system, steroid 21-hydroxylation system, steroid cytochrome P450 21-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.16 steroid 21-monooxygenase

Inhibitors

Inhibitors on EC 1.14.14.16 - steroid 21-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17alpha-hydroxyprogesterone
inhibits above 0.2mM
antibody to cytochrome P-450BPA
-
-
-
antibody to NADPH-cytochrome P-450 reductase
-
-
-
antimycin A
-
15% inhibition at 1mg per l
ascorbate
azide
-
9% inhibition at 1 mM
carbon monoxide
CuSO4
cyanide
-
14% inhibition at 1 mM
cytochrome b5
-
-
cytochrome c
-
complete inhibition at 0.1 mM, 0.003 mM
diethylaminoethyldiphenylpropylacetic acid SKF 525 A
-
9% inhibition at 1 mM
fluoxetine
-
50% inhibition at 0.002 mM, substrate allopregnanolone
HgCl2
-
complete inhibition at 0.1 mM
ketoconazole
-
inhibits hydroxylation activity with progesterone and 17-fluoroprogesterone to the same amount
p-chloromercuribenzoate
-
complete inhibition at 1 mM, but not inhibitory at 0.1 mM
Phenylisocyanide
-
inhibition at 0.5 mM
progesterone
-
-
quinidine
-
-
resveratrol
-
decreases adrenal enzyme expression in vivo and in cell culture. Corticosterone production is inhibited 47% by 0.05 mM resveratrol in vitro and 20% ex vivo, while progesterone production is elevated to 400% of control in vitro
RU38486
-
-
sodium o-(3-hydroxymercuri-2-methoxypropyl)carbamyl-phenoxyacetc acid (mersalyl)
-
complete inhibition at 1 mM
additional information
-