Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.14.17: squalene monooxygenase

This is an abbreviated version!
For detailed information about squalene monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.17

Reaction

squalene
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
(3S)-2,3-epoxy-2,3-dihydrosqualene
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, EC 1.14.13.132, EC 1.14.99.7, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, PgSQE1, PgSQE2, SE, SE1, SE3, SQE, SQE-I, SQE-II, sqe1, SQE3, SQLE, squalen expoxidase, squalene 2,3-epoxidase, squalene 2,3-oxidocyclase, squalene epoxidase, squalene epoxidase 1, squalene epoxidase 3, squalene hydroxylase, squalene mono-oxygenase, squalene oxydocyclase, squalene-2,3-epoxidase, squalene-2,3-epoxide cyclase, TkSQE1, TkSQE2, TkSQE3, TkSQE4

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.17 squalene monooxygenase

Cloned

Cloned on EC 1.14.14.17 - squalene monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Arabidopsis drought hypersensitive/squalene epoxidase 1-5 mutant is extremely hypersensitivity to drought stress (squalene epoxidase knocked out), stomatal and root defects of the mutant are associated with altered production of reactive oxygen species
-
cloning from mycelial powder, DNA and amino acid sequence determination and analysis, sequence comparisons
-
DNA and amino acid sequence determination and analysis of terbinafine-resistant strains/patient isolates
-
DNA and amino acid sequence determination and analysis, expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
-
DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli strain BL21(DE3)
DNA and amino acid sequence determination and analysis, quantitative expression analysis, phylogenetic tree
expressed in CHO-7 and HEK-293 cells
-
expressed in HEK-293 cells
-
expression in CHO-7 cell
Q9UNR6
expression in Escherichia coli
-
expression in Ganoderma lucidum
expression of cDNA in Escherichia coli
expression of His-tagged cytochrome P450 17alpha hydroxylase/17,20 lyase CYP17 in Escherichia coli
-
expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
-
expression of mutant L398F in Saccharomyces cerevisiae strain INVSc1
-
expression of wild-type and mutant enzymes in erg1-knockout strain KLN1
-
gene ERG1, subcloning in Escherichi acoli strain DH5alpha
-
gene PgSQE1, DNA and amino acid sequence determination and analysis, phylogenetic analysis
B7TWW5, Q75W20
gene PgSQE2, DNA and amino acid sequence determination and analysis, phylogenetic analysis
B7TWW5, Q75W20
gene sq1-1 encoding isozyme SQ1, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in enzyme-deficient Saccharomyces cerevisiae strain RXY6.2
gene sq1-2 encoding isozyme SQ2, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in enzyme-deficient Saccharomyces cerevisiae strain RXY6.2
gene sq1-4 encoding isozyme SQ4, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in enzyme-deficient Saccharomyces cerevisiae strain RXY6.2
methyl jasmonate treatment suppresses PgSQE2 mRNA expression
B7TWW5, Q75W20
mRNA expression of squalene epoxidase is associated with ER+ 7p+/8q+ breast cancer (mRNA analysis of tumor patients)
-
single-copy gene, DNA and amino acid sequence determination and analysis, expression in and complementation of erg1-disrupted Saccharomyces cerevisiae mutant strain KLN1