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1.14.14.21: dibenzothiophene monooxygenase

This is an abbreviated version!
For detailed information about dibenzothiophene monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.21

Reaction

dibenzothiophene
+ 2 FMNH2 + 2 O2 =
dibenzothiophene-5,5-dioxide
 + 2 FMN + 2 H2O

Synonyms

BdsC, benzothiophene monooxygenase, BT monooxygenase, cofactor-requiring dibenzothiophene monooxygenase, DBT monooxygenase, DBT-MO, DBT-monooxygenase, dibenzothiophene monooxygenase, dszC, TdsC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.21 dibenzothiophene monooxygenase

Inhibitors

Inhibitors on EC 1.14.14.21 - dibenzothiophene monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2,2'-dithiobis(5-nitropyridine)
-
-
4-chloromercuribenzoate
-
-
4-chloromercuribenzoic acid
-
5,5'-dithio-bis-2-nitrobenzoic acid
94% inhibition at 0.5 mM
8-Quinolinol
-
-
CaCl2
16% inhibition at 1 mM
CoCl2
74% inhibition at 1 mM
CuCl2
complete inhibition at 1 mM
diethyldithiocarbamate
-
-
EDTA
68% inhibition at 1 mM
FAD
the flavin at high concentrations inhibits the activity of DszC due to autocatalytic oxidation of reduced flavin, formation of H2O2
FMN
the flavin at high concentrations inhibits the activity of DszC due to autocatalytic oxidation of reduced flavin, formation of H2O2
iodoacetate
46% inhibition at 1 mM
MnCl2
66% inhibition at 1 mM
N-ethylmaleimide
98% inhibition at 1 mM
p-chloromercuribenzoic acid
complete inhibition at 0.5 mM
ZnCl2
complete inhibition at 1 mM
additional information
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