1.14.14.25: cholesterol 24-hydroxylase

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For detailed information about cholesterol 24-hydroxylase, go to the full flat file.

Reaction

Synonyms

24S-hydroxylase, CH24H, cholesterol 24-hydroxylase, cholesterol 24-monooxygenase, cholesterol 24S hydroxylase, cholesterol 24S-hydroxylase, cholesterol hydroxylase, cholesterol-24S-hydroxylase, CYP46, CYP46A, CYP46A1, cytochrome P-450 46A1, cytochrome P450 46A1, cytochrome P450 cholesterol 24-hydroxylase, EC 1.14.13.98

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.25 cholesterol 24-hydroxylase

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Results	in table
5	Activating Compound
14	AA Sequence
6	Application
2	CAS Registry Number
25	Cloned(Commentary)
49	Cofactor
2	Crystallization (Commentary)
350	Disease/ Diagnostics
11	Expression
32	General Information
19	Inhibitors
1	Ki Value [mM]
10	KM Value [mM]
20	Localization
2	Metals/Ions
5	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
235	Organism
1	Pathway
6	PDB ID
2	pH Optimum
16	Protein Variants
5	Purification (Commentary)
2	Reaction
3	Reaction Type
68	Reference
132	Source Tissue
77	Substrates and Products (Substrate)
5	Subunits
88	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
9	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.14.14.25 - cholesterol 24-hydroxylase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

a recombinant C-terminally His4-tagged CYP46A1 lacking the first 50 N-terminal amino acid residues, substrate-free enzyme or enzyme in complex with cholesterol 3-sulfate, X-ray diffraction structure determination and analysis at 2.4 A and 1.9 A resolution, respectively, structure modeling

Homo sapiens

Q9Y6A2

689814

analysis of the crystal structure of cholesterol sulfate-bound CYP46A1, PDB ID 2Q9F

Homo sapiens

Q9Y6A2

736502