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1.14.14.26: 24-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 24-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.26

Reaction

(24S)-cholest-5-ene-3beta,24-diol
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
(24S)-cholest-5-ene-3beta,7alpha,24-triol
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

24-hydroxycholesterol 7alpha-monooxygenase, Cyp39a1, CYP39A1 oxysterol 7alpha-hydroxylase, EC 1.14.13.99, oxysterol 7alpha-hydroxylase CYP39A1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.26 24-hydroxycholesterol 7alpha-hydroxylase

Disease

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Disease on EC 1.14.14.26 - 24-hydroxycholesterol 7alpha-hydroxylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma, Hepatocellular
Orphan Nuclear Receptor ROR? Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation.
Cholangiocarcinoma
Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression.
Colorectal Neoplasms
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
COVID-19
Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology.
Exfoliation Syndrome
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.
Head and Neck Neoplasms
CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer.
Infections
CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer.
Liver Diseases
Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology.
Neoplasm Metastasis
Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression.
Neutropenia
An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel.
Prostatic Neoplasms
Ligand-binding properties and catalytic activity of the purified human 24-hydroxycholesterol 7?-hydroxylase, CYP39A1.