1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase
This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.29
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1.14.14.29
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oxysterols
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bile
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cyp27a1
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27-hydroxycholesterol
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paraplegia
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dehydroepiandrosterone
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neurosteroids
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7alpha-hydroxylation
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27-hydroxylase
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interferon-stimulated
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lithogenic
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cholesterol-25-hydroxylase
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7alpha-hydroxy-dhea
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5alpha-androstane-3beta,17beta-diol
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7-hydroxylation
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cyp2b9
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medicine
- 1.14.14.29
- oxysterols
- bile
- cyp27a1
- 27-hydroxycholesterol
- paraplegia
- dehydroepiandrosterone
-
neurosteroids
-
7alpha-hydroxylation
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27-hydroxylase
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interferon-stimulated
-
lithogenic
- cholesterol-25-hydroxylase
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7alpha-hydroxy-dhea
- 5alpha-androstane-3beta,17beta-diol
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7-hydroxylation
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cyp2b9
- medicine
Reaction
Synonyms
25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase
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Inhibitors
Inhibitors on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase
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dehydroepiandrosterone
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inhibits hydroxylation of 5alpha-androstane-3beta,17beta-diol
LY294002
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specific inhibitor of phosphatidylinositol 3-kinase, abolishes estrogen receptor-mediated upregulation of a CYP7B1 promoter-luciferase reporter in Hep-G2 cells but not in HEK-293 cells
PD98059
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markedly suppresses basal CYP7B1 promoter activity, abolishes upregulation of CYP7B1 by estrogen receptor in Hep-G2 cells
SP600125
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markedly suppresses basal CYP7B1 promoter activity, abolishes upregulation of CYP7B1 by estrogen receptor in Hep-G2 cells but not in HEK-293 cells
inhibition of the reaction with dehydroepiandrosterone
5alpha-androstane-3alpha,17beta-diol
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inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation
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inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%. In HEK293 cells, the suppressive effect of 5alpha-androstane-3beta,17beta-diol on dehydroepiandrosterone metabolism is statistically significant also at a 10fold lower concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture
5alpha-Androstane-3beta,17beta-diol
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inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%
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overexpression of Akt, in the absence of estrogen stimulation, suppresses basal CYP7B1 promoter activity by about 75%. Overexpression of dominant-negative mutant Akt abolishes estrogen receptor-mediated stimulation of CYP7B1 in Hep-G2 cells
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additional information
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mRNA encoding CYP39A1 gene is significantly repressed by pregnane X receptor activation in primary hepatocytes of wild-type mice but not in pregnane X receptor-/- hepatocytes
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additional information
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no inhibition: testosterone, dehydroepiandrosterone sulfate
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additional information
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testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities
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