1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Reaction

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

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Results	in table
1	Activating Compound
4	AA Sequence
1	Application
2	CAS Registry Number
6	Cloned(Commentary)
19	Cofactor
391	Disease/ Diagnostics
3	Expression
8	General Information
13	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
8	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
8	Protein Variants
4	Reaction
3	Reaction Type
30	Reference
38	Source Tissue
46	Substrates and Products (Substrate)
2	Subunits
45	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3alpha-adiol

Homo sapiens

O75881

-

728174

5alpha-androstane-3alpha,17beta-diol

2 entries

5alpha-Androstane-3beta,17beta-diol

2 entries

dehydroepiandrosterone

Sus scrofa

-

inhibits hydroxylation of 5alpha-androstane-3beta,17beta-diol

686694

LY294002

Homo sapiens

-

specific inhibitor of phosphatidylinositol 3-kinase, abolishes estrogen receptor-mediated upregulation of a CYP7B1 promoter-luciferase reporter in Hep-G2 cells but not in HEK-293 cells

705397

PD98059

Homo sapiens

-

markedly suppresses basal CYP7B1 promoter activity, abolishes upregulation of CYP7B1 by estrogen receptor in Hep-G2 cells

705397

SP600125

Homo sapiens

-

markedly suppresses basal CYP7B1 promoter activity, abolishes upregulation of CYP7B1 by estrogen receptor in Hep-G2 cells but not in HEK-293 cells

705397

additional information

4 entries

-

5alpha-androstane-3alpha,17beta-diol

Homo sapiens

O75881

inhibition of the reaction with dehydroepiandrosterone

702427

5alpha-androstane-3alpha,17beta-diol

Sus scrofa

-

inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation

702427

5alpha-Androstane-3beta,17beta-diol

Homo sapiens

-

inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%. In HEK293 cells, the suppressive effect of 5alpha-androstane-3beta,17beta-diol on dehydroepiandrosterone metabolism is statistically significant also at a 10fold lower concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture

686694

5alpha-Androstane-3beta,17beta-diol

Sus scrofa

-

inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%

686694

additional information

Homo sapiens

-

overexpression of Akt, in the absence of estrogen stimulation, suppresses basal CYP7B1 promoter activity by about 75%. Overexpression of dominant-negative mutant Akt abolishes estrogen receptor-mediated stimulation of CYP7B1 in Hep-G2 cells

705397

-

additional information

Mus musculus

-

mRNA encoding CYP39A1 gene is significantly repressed by pregnane X receptor activation in primary hepatocytes of wild-type mice but not in pregnane X receptor-/- hepatocytes

705003

-

additional information

Sus scrofa

-

no inhibition: testosterone, dehydroepiandrosterone sulfate

686694

-

additional information

Sus scrofa

-

testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities

702427

-