1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Reaction

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
4	AA Sequence
1	Application
2	CAS Registry Number
6	Cloned(Commentary)
19	Cofactor
391	Disease/ Diagnostics
3	Expression
8	General Information
13	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
8	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
8	Protein Variants
4	Reaction
3	Reaction Type
30	Reference
38	Source Tissue
46	Substrates and Products (Substrate)
2	Subunits
45	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Natural Substrates Products on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

25-hydroxycholesterol + NADPH + H+ + O2

? + NADP+ + H2O

Homo sapiens

O75881

-

728174

-

-

?

27-hydroxycholesterol + NADPH + H+ + O2

3beta,7alpha-dihydroxy-5-cholestenoic acid + NADP+ + H2O

Homo sapiens

O75881

-

728174

-

-

?

cholest-5-ene-3beta,25-diol + NADPH + H+ + O2

cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O

3 entries

cholest-5-ene-3beta,27-diol + NADPH + H+ + O2

cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

2 entries

dehydroepiandrosterone + NADPH + H+ + o2

7alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O

Homo sapiens

O75881

-

728174

-

-

?

additional information

?

-

4 entries

cholest-5-ene-3beta,25-diol + NADPH + H+ + O2

cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O

Mus musculus

Q60991

CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids

657550

-

-

?

cholest-5-ene-3beta,25-diol + NADPH + H+ + O2

cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O

Mus musculus

-

dietary cholesterol or colestipol do not affect oxysterol 7alpha-hydroxylase enzyme activity, mRNA, or protein levels

7410

-

-

?

cholest-5-ene-3beta,25-diol + NADPH + H+ + O2

cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O

Mus musculus

-

loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways

659142

-

-

?

cholest-5-ene-3beta,27-diol + NADPH + H+ + O2

cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

Mus musculus

Q60991

CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids

657550

-

-

?

cholest-5-ene-3beta,27-diol + NADPH + H+ + O2

cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

Mus musculus

-

loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways

659142

-

-

?

additional information

?

-

Homo sapiens

-

regulation of CYP7B1 transcription by Sp1 may play a pivotal role in regulating oxysterol levels, which regulate cholesterol metabolism

658818

-

-

?

additional information

?

-

Mus musculus

-

retinoid-related orphan receptor alpha positively and directly regulates the expression of Cyp7b1

689077

-

-

?

additional information

?

-

Rattus norvegicus

-

both phorbol myristate acetate and cAMP decreases CYP7B1 activity by 60% and 34% respectively, in a time-dependent fashion. Changes in CYP7B1 messenger RNA levels correlate with changes in specific activities. CYP7B1 specific activity is highly regulated but does not seem to be rate limiting for bile acid synthesis

658874

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is regulated by bile acids and cholesterol

659851

-

-

?