1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

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For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.29

1.14.14.29

oxysterols

bile

cyp27a1

27-hydroxycholesterol

paraplegia

dehydroepiandrosterone

neurosteroids

7alpha-hydroxylation

27-hydroxylase

interferon-stimulated

lithogenic

cholesterol-25-hydroxylase

7alpha-hydroxy-dhea

5alpha-androstane-3beta,17beta-diol

7-hydroxylation

cyp2b9

medicine

Reaction

(25R)-cholest-5-ene-3beta,7alpha,26-triol

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

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Results	in table
1	Activating Compound
4	AA Sequence
1	Application
2	CAS Registry Number
6	Cloned(Commentary)
19	Cofactor
391	Disease/ Diagnostics
3	Expression
8	General Information
13	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
8	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
8	Protein Variants
4	Reaction
3	Reaction Type
30	Reference
38	Source Tissue
46	Substrates and Products (Substrate)
2	Subunits
45	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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of prostate

bone marrow-derived

CYP7B1 is overexpressed in high-grade prostatic intraepithelial neoplasia and in prostate cancer

689846

prostate gland

Homo sapiens

CYP7B1 is overexpressed in high-grade prostatic intraepithelial neoplasia and in prostate cancer

689846

prostatic intraepithelial neoplasia cell

Homo sapiens

CYP7B1 is overexpressed in high-grade prostatic intraepithelial neoplasia and in prostate cancer

activity is detected in keratinocytes of the spinous and granula layers, and to lesser extent in the basal layer and basal cell bodies. High activity in hair follicle associated cells

CYP7B1 occurrs in trabecular stroma cells

688678

additional information

Mesocricetus auratus

CYP7B1 is elevated by 1.5 days postpartum compared with other ages, levels decrease in the midneonatal period and then increase by 20.5 days postpartum

695480