1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

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For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

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Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

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Results	in table
19	Activating Compound
818	AA Sequence
10	Application
1	CAS Registry Number
20	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
3627	Disease/ Diagnostics
5	Expression
11	General Information
84	IC50 Value
170	Inhibitors
11	kcat/KM [mM/s]
10	Ki Value [mM]
20	KM Value [mM]
38	Localization
3	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
207	Organism
7	Pathway
26	PDB ID
2	pH Optimum
2	Posttranslational Modification
32	Protein Variants
3	Reaction
9	Reaction Type
67	Reference
84	Source Tissue
15	Specific Activity [micromol/min/mg]
117	Substrates and Products (Substrate)
2	Subunits
109	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

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SYSTEMATIC NAME

IUBMB Comments

17alpha-hydroxyprogesterone,NADPH—hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)

A microsomal cytochrome P-450 (heme-thiolate) protein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3beta-hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis. The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome [2,4]. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [1].