Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.14.51: (S)-limonene 6-monooxygenase

This is an abbreviated version!
For detailed information about (S)-limonene 6-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.51

Reaction

(S)-limonene
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(-)-trans-carveol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

(+)-limonene-6-hydroxylase, (-)-(4S)-limonene-6-hydroxylase, (-)-limonene 6-hydroxylase, (-)-limonene 6-monooxygenase, (-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating), (-)-limonene-6-hydroxylase, 4S-limonene-6-hydroxylase, EC 1.14.13.48, limonene hydroxylase, limonene-6-hydroxylase, oxygenase, (-)-limonene 6-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.51 (S)-limonene 6-monooxygenase

Reference

Reference on EC 1.14.14.51 - (S)-limonene 6-monooxygenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gershenzon, J.; Maffei, M.; Croteau, R.
Biochemical and histochemical localization of monoterpene biosynthesis in the glandular trichomes of spearmint (Mentha spicata)
Plant Physiol.
89
1351-1357
1989
Mentha spicata
Manually annotated by BRENDA team
Karp, F.; Mihaliak, C.A.; Harris, J.L.; Croteau, R.
Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves
Arch. Biochem. Biophys.
276
219-226
1990
Mentha spicata
Manually annotated by BRENDA team
Croteau, R.; Karp, F.; Wagschal, K.C.; Satterwhite, M.; Hyatt, D.C.; Skotland, C.B.
Biochemical characterization of a spearmint mutant that resembles peppermint in monoterpene content
Plant Physiol.
96
744-752
1991
Mentha x gracilis
Manually annotated by BRENDA team
Gershenzon, J.; McCaskill, D.; Rajaonarivony, J.I.; Mihaliak, C.; Karp, F.; Croteau, R.
Isolation of secretory cells from plant glandular trichomes and their use in biosynthetic studies of monoterpenes and other gland products
Anal. Biochem.
200
130-138
1992
Mentha spicata
Manually annotated by BRENDA team
Schalk, M.; Croteau, R.
A single amino acid substitution (F363I) converts the regiochemistry of the spearmint (-)-limonene hydroxylase from a C6- to a C3-hydroxylase
Proc. Natl. Acad. Sci. USA
97
11948-11953
2000
Mentha spicata
Manually annotated by BRENDA team
Lupien, S.; Karp, F.; Wildung, M.; Croteau, R.
Regiospecific cytochrome P450 limonene hydroxylases from mint (Mentha) species: cDNA isolation, characterization, and functional expression of (-)-4S-limonene-3-hydroxylase and (-)-4S-limonene-6-hydroxylase
Arch. Biochem. Biophys.
368
181-192
1999
Mentha spicata (Q9XHE8), Mentha spicata
Manually annotated by BRENDA team
Haudenschild, C.; Schalk, M.; Karp, F.; Croteau, R.
Functional expression of regiospecific cytochrome P450 limonene hydroxylases from mint (Mentha spp.) in Escherichia coli and Saccharomyces cerevisiae
Arch. Biochem. Biophys.
379
127-136
2000
Mentha spicata
Manually annotated by BRENDA team
Wust, M.; Little, D.B.; Schalk, M.; Croteau, R.
Hydroxylation of limonene enantiomers and analogs by recombinant (-)-limonene 3- and 6-hydroxylases from Mint (Mentha) species: Evidence for catalysis within sterically constrained active sites
Arch. Biochem. Biophys.
387
125-136
2001
Mentha spicata
Manually annotated by BRENDA team
Wuest, M.; Croteau, R.B.
Hydroxylation of specifically deuterated limonene enantiomers by cytochrome P450 limonene-6-hydroxylase reveals the mechanism of multiple product formation
Biochemistry
41
1820-1827
2002
Mentha spicata
Manually annotated by BRENDA team
Lupien, S.; Karp, F.; Ponnamperuma, K.; Wildung, M.; Croteau, R.
Cytochrome P450 limonene hydroxylases of Mentha species
Drug Metabol. Drug Interact.
12
245-260
1995
Mentha spicata
Manually annotated by BRENDA team
Carter, O.A.; Peters, R.J.; Croteau, R.
Monoterpene biosynthesis pathway construction in Escherichia coli
Phytochemistry
64
425-433
2003
Mentha spicata
Manually annotated by BRENDA team
Shimada, T.; Shindo, M.; Miyazawa, M.
Species differences in the metabolism of (+)- and (-)-limonenes and their metabolites, carveols and carvones, by cytochrome P450 enzymes in liver microsomes of mice, rats, guinea pigs, rabbits, dogs, monkeys, and humans
Drug Metab. Pharmacokinet.
17
507-515
2002
Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Macaca fascicularis, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Turner, G.W.; Croteau, R.
Organization of monoterpene biosynthesis in Mentha. Immunocytochemical localizations of geranyl diphosphate synthase, limonene-6-hydroxylase, isopiperitenol dehydrogenase, and pulegone reductase
Plant Physiol.
136
4215-4227
2004
Mentha spicata
Manually annotated by BRENDA team
Hamada, H.; Kondo, Y.; Ishihara, K.; Nakajima, N.; Kurihara, R.; Hirata, T.
Stereoselective biotransformation of limonene and limonene oxide by cyanobacterium, Synechococcus sp. PCC 7942
J. Biosci. Bioeng.
96
581-584
2003
Synechococcus sp., Synechococcus sp. PCC 7942
Manually annotated by BRENDA team
Cheong, T.; Oriel, P.
Cloning and expression of the limonene hydroxylase of Bacillus stearothermophilus BR388 and utilization in two-phase limonene conversions
Appl. Biochem. Biotechnol.
84-86
903-915
2000
Geobacillus stearothermophilus (O85057), Geobacillus stearothermophilus, Geobacillus stearothermophilus BR388 (O85057)
Manually annotated by BRENDA team
Bouwmeester, H.; Konings, M.; Gershenzon, J.; Karp, F.; Croteau, R.
Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum carvi)
Phytochemistry
50
243-248
1999
Carum carvi
-
Manually annotated by BRENDA team