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1.14.14.55: quinine 3-monooxygenase

This is an abbreviated version!
For detailed information about quinine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.55

Reaction

Quinine
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
3-hydroxyquinine
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP2C19, CYP3A, CYP3A4, CYPIIIA4, cytochrome P450 isoform, EC 1.14.13.67, NF-25, Nifedipine oxidase, P450-PCN1, quinine 3-hydroxylase, Quinine 3-monooxygenase, quinine monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.55 quinine 3-monooxygenase

General Information

General Information on EC 1.14.14.55 - quinine 3-monooxygenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
differences in the activity of both CYP3A4 and CYP3A5 in Koreans, Swedes and Tanzanians. Both 4beta-hydroxycholesterol and quinine/3-hydroxyquinine metabolic ratio show a higher CYP3A activity in women than in men