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1.14.14.56: 1,8-cineole 2-exo-monooxygenase

This is an abbreviated version!
For detailed information about 1,8-cineole 2-exo-monooxygenase, go to the full flat file.

Reaction

1,8-cineole
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
2-exo-hydroxy-1,8-cineole
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP3A4, CYP3A5, EC 1.14.13.157

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.56 1,8-cineole 2-exo-monooxygenase

Reference

Reference on EC 1.14.14.56 - 1,8-cineole 2-exo-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Duisken, M.; Sandner, F.; Bloemeke, B.; Hollender, J.
Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite
Biochim. Biophys. Acta
1722
304-311
2005
Homo sapiens
Manually annotated by BRENDA team
Miyazawa, M.; Shindo, M.; Shimada, T.
Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes
Drug Metab. Dispos.
29
200-205
2001
Rattus norvegicus
Manually annotated by BRENDA team
Miyazawa, M.; Shindo, M.; Shimada, T.
Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes
Xenobiotica
31
713-723
2001
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team