1.14.14.61: carnosic acid synthase
This is an abbreviated version!
For detailed information about carnosic acid synthase, go to the full flat file.
Reaction
+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
Synonyms
CYP76AK6, CYP76AK7, CYP76AK8
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.61 - carnosic acid synthase
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REACTION DIAGRAM
11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
ferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
pisiferic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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?
11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
-
-
?
11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
-
-
-
?
pisiferic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
-
-
?
ferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
pisiferic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
-
-
-
?
?
-
-
reaction intermediates are 11,20-dohydroxyferruginol and carnosaldehyde, which itself spontaneously oxidizes to carnosol. The enzyme can also oxidize miltiradiene and ferruginol, thelatter leading to pisifieric acid, albeit with much lower efficiency, indicating 11-hydroxyferruginol is their preferred substrate
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-
?
additional information
?
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CYP76AK6 is a multifunctional enzyme that catalyzes successive oxidation events at C-20 of the labdane skeleton
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-
?
additional information
?
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reaction intermediates are 11,20-dohydroxyferruginol and carnosaldehyde, which itself spontaneously oxidizes to carnosol. The enzyme can also oxidize miltiradiene and ferruginol, the latter leading to pisifieric acid, albeit with much lower efficiency, indicating 11-hydroxyferruginol is their preferred substrate
-
-
?
additional information
?
-
-
CYP76AK6 is a multifunctional enzyme that catalyzes successive oxidation events at C-20 of the labdane skeleton
-
-
?
additional information
?
-
-
reaction intermediates are 11,20-dohydroxyferruginol and carnosaldehyde, which itself spontaneously oxidizes to carnosol. The enzyme can also oxidize miltiradiene and ferruginol, the latter leading to pisifieric acid, albeit with much lower efficiency, indicating 11-hydroxyferruginol is their preferred substrate
-
-
?