1.14.14.B11: nicotine demethylase

This is an abbreviated version!
For detailed information about nicotine demethylase, go to the full flat file.

CYP82E, CYP82E1, CYP82E10, CYP82E2, CYP82E21, CYP82E3, CYP82E4, CYP82E4v1, CYP82E5v2, nicotine N-demethylase, NND

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Results	in table
1	Activating Compound
10	AA Sequence
3	Application
1	CAS Registry Number
10	Cloned(Commentary)
21	Cofactor
1	Disease/ Diagnostics
1	Expression
5	General Information
10	Inhibitors
13	KM Value [mM]
5	Localization
1	Metals/Ions
13	Natural Substrates/ Products (Substrates)
23	Organism
15	Protein Variants
2	Reaction
18	Reference
23	Source Tissue
20	Substrates and Products (Substrate)
26	Synonyms
1	Systematic Name

Natural Substrates Products on EC 1.14.14.B11 - nicotine demethylase

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(R)-nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2

(R)-nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O

isoforms CYP82E4, CYP82E5v2, and CYP82E10 demethylate (R)-nicotine 3, 10, and 10fold faster than (S)-nicotine, respectively

(S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2

(S)-nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O

nicotine + NADPH + H+

nornicotine + NADP+

nicotine + NADPH + O2 + H+

nornicotine + formaldehyde + NADP+ + H2O

demethylates nicotine to form nornicotine, a precursor to the nitrosamine N'-nitrosonornicotine

nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2

nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O

nicotine + [reduced NADPH-hemoprotein reductase] + O2

nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O