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1.14.14.B11: nicotine demethylase

This is an abbreviated version!
For detailed information about nicotine demethylase, go to the full flat file.

Word Map on EC 1.14.14.B11

Reaction

(R)-nicotine
+
O2
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(R)-nornicotine
+
formaldehyde
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP82E, CYP82E1, CYP82E10, CYP82E2, CYP82E21, CYP82E3, CYP82E4, CYP82E4v1, CYP82E5v2, nicotine N-demethylase, NND

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.B11 nicotine demethylase

Source Tissue

Source Tissue on EC 1.14.14.B11 - nicotine demethylase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
regarding sepals, petals, ovaries, stigma including style, filaments and anthers, CYP82E21 expression is found almost exclusively in ovaries, with very low expression levels observed in other flower organs
Manually annotated by BRENDA team
-
nicotine N-demethylase activity in microsomes from human livers at 0.02 mM nicotine is significantly correlated with the isoform CYP2A6 contents, while the nicotine N-demethylase activity at 0.1 mM nicotine is significantly correlated with the isoform CYP2B6 contents
Manually annotated by BRENDA team
-
specific for
Manually annotated by BRENDA team
-
specific for
Manually annotated by BRENDA team
Q38Q86
-
Manually annotated by BRENDA team
additional information
-
CYP82E21 expression pattern analysis, CYP82E21 is specifically expressed in ovaries but not expressed in leaves
Manually annotated by BRENDA team