Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.15.3: alkane 1-monooxygenase

This is an abbreviated version!
For detailed information about alkane 1-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.3

Reaction

Octane
+
reduced rubredoxin
+
O2
+ 2 H+ =
1-Octanol
+
oxidized rubredoxin
+
H2O

Synonyms

1-hydroxylase, alkane 1-hydrolase, alkane hydroxylase, alkane mono-oxygenase, alkane monooxygenase, alkane omega-hydroxylase, alkane-1-monooxygenase 1, alkane-1-monooxygenase 2, AlkB, AlkB1, AlkB2, AlkW1, AlkW2, AlmA, AlmA-like alkane hydroxylase, BMO, butane monooxygenase, CYP omega hydroxylase, CYP omega-hydroxylase, Cyp153, CYP153 homologue, CYP153A, CYP153D17, CYP4 P450, CYP450 4A omega-hydroxylase, CYP450 omega-hydroxylase, CYP4A, CYP4A10, CYP4A11, CYP4A14, CYP4AII, CYP4d21, CYP86A1, CYP86B1, CYP94A1, CYPA11 P450, CYPIVA1, CYPIVA11, CYPIVA2, CYPIVA3, CYPIVA5, CYPIVA6, CYPIVA7, cytochrome P-450 omega-hydroxylase, cytochrome P450 alkane hydroxylase, cytochrome P450 omega hydroxylase, cytochrome P450-dependent fatty acid omega-hydroxylase, diiron omega-hydroxylase, FA omega-hydroxylase, fatty acid omega-hydrolase, Fatty acid omega-hydroxylase, Gpo1, hexane hydroxylase, Lauric acid omega-hydroxylase, MAH1-1, MAH1-2, male-specific fatty acid omega-hydroxylase, medium-chain alkane hydroxylase, methane monooxygenase, More, omega hydroxylase, omega-hydrolase, omega-hydroxylase, P-450 HK omega, P450-HL-omega, P452, Prm1ABCD, Prm2ABCD, propane monooxygenase, Rieske-type alkane monooxygenase, sex-specific enzyme 1, SXE1, UAM-Ps1, very long chain fatty acid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.3 alkane 1-monooxygenase

Substrates Products

Substrates Products on EC 1.14.15.3 - alkane 1-monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
show the reaction diagram
1,1-diethylcyclopropane + NADPH + H+ + O2
?
show the reaction diagram
1,7-octadiene + NADH + H+ + O2
1,2-epoxy-7-octene + NAD+ + H2O
show the reaction diagram
-
epoxidation of simple, aliphatic terminal olefins
-
-
?
1-hexadecene + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
1-octadecene + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
1-octene + reduced rubredoxin + O2
1,2-epoxyoctane + oxidized rubredoxin + H2O
show the reaction diagram
2 1-octyne + 2 NADH + 2 H+ + 2 O2
1-octanoic acid + 7-octynoic acid + 2 NAD+ + 2 H2O
show the reaction diagram
-
-
-
-
?
2,5-dimethylhexane + NADH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
5,8,11-eicosatrienoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
show the reaction diagram
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
show the reaction diagram
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
show the reaction diagram
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
show the reaction diagram
bicyclohexane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
show the reaction diagram
-
i.e. bicyclo[3.1.0]hexane, no distinction between the 2- and 3-positions, reaction via formation of a substrate radical that persists in the active site
-
-
?
butane + NADPH + H+ + O2
1-butanol + NADP+ + H2O
show the reaction diagram
cycloheptane + NAD(P)H + H+ + O2
cycloheptanol + NAD(P)+ + H2O
show the reaction diagram
cyclohexane + NAD(P)H + H+ + O2
cyclohexanol + NAD(P)+ + H2O
show the reaction diagram
cyclohexane + NADH + H+ + O2
cyclohexanol + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
cyclooctane + NAD(P)H + H+ + O2
cyclooctanol + NAD(P)+ + H2O
show the reaction diagram
cyclopentane + NAD(P)H + H+ + O2
cyclopentanol + NAD(P)+ + H2O
show the reaction diagram
-
very poor substrate
-
-
?
decane + reduced rubredoxin + O2
1-decanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
decane + reduced rubredoxin + O2 + H+
1-decanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
r
dicyclopropylketone + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
show the reaction diagram
-
-
-
?
docosahexaenoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
show the reaction diagram
-
-
-
-
?
dodecane + reduced rubredoxin + O2
1-dodecanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
eicosapentaenoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
show the reaction diagram
-
is less omega-hydroxylated than 5,8,11-eicosatrienoic acid and arachidonic acid
-
-
?
ethyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
show the reaction diagram
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
show the reaction diagram
heptadecane + reduced rubredoxin + O2
1-heptadecanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
heptanoate + NADPH + H+ + O2
?
show the reaction diagram
-
59% activity compared to octane
-
-
r
hexadecane + reduced rubredoxin + O2
1-hexadecanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
hexane + reduced rubredoxin + O2
1-hexanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
hexane + reduced rubredoxin + O2 + H+
1-hexanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
r
hexanoate + NADPH + H+ + O2
?
show the reaction diagram
-
25% activity compared to octane
-
-
r
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
show the reaction diagram
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxydodecanoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
-
?
lecithin + NADH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
methane + NADPH + H+ + O2
methanol + NADP+ + H2O
show the reaction diagram
methane sulfonic acid + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O
show the reaction diagram
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + methanol
show the reaction diagram
-
-
-
?
methylcyclohexane + NADH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
methylphenylcyclopropane + reduced rubredoxin + O2
1-phenylbut-3-en-1-ol + oxidized rubredoxin + H2O
show the reaction diagram
-
reaction via formation of a substrate radical that persists in the active site
-
-
?
monoolein + NADH + H+ + O2
18-hydroxyoctadec-9-enoic acid 2,3-dihydroxypropyl ester + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
show the reaction diagram
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
show the reaction diagram
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
show the reaction diagram
n-butane + reduced rubredoxin + O2
1-butanol + oxidized rubredoxin + H2O
show the reaction diagram
n-dodecane + 2 reduced rubredoxin + O2 + 2 H+
1-dodecanol + 2 oxidized rubredoxin + H2O
show the reaction diagram
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
show the reaction diagram
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
show the reaction diagram
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
show the reaction diagram
n-propane + reduced rubredoxin + O2
1-propanol + oxidized rubredoxin + H2O
show the reaction diagram
nitromethane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
nonanoate + NADPH + H+ + O2
?
show the reaction diagram
-
25% activity compared to octane
-
-
r
norcarane + NADPH + H+ + O2
?
show the reaction diagram
norcarane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
show the reaction diagram
-
i.e. bicyclo[4.1.0]heptane, oxidation preferentially occurs at the less sterically hindered 3-position, reaction via formation of a substrate radical that persists in the active site
-
-
?
octadecane + reduced rubredoxin + O2
1-octadecanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
show the reaction diagram
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
show the reaction diagram
pentadecane + reduced rubredoxin + O2
1-pentadecanol + oxidized rubredoxin + H2O
show the reaction diagram
-
best substrate
-
-
?
pentane + reduced rubredoxin + O2
1-pentanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
phosphatidylethanolamine + NADH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
phosphatidylserine + NADH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
propane + NADPH + H+ + O2
1-propanol + NADP+ + H2O
show the reaction diagram
propane + NADPH + H+ + O2
propan-1-ol + NADP+ + H2O
show the reaction diagram
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9
-
-
-
?
propane + NADPH + H+ + O2
propanol + NADP+ + H2O
show the reaction diagram
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
?
show the reaction diagram
prostaglandin A2 + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
prostaglandin E1 + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
spirooctane + NADPH + H+ + O2
?
show the reaction diagram
stearic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
show the reaction diagram
-
-
-
-
?
suberin + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
?
tert-amyl methyl ether + NAD(P)H + H+ + O2
tert-amyl-alcohol + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
tetracosane + reduced rubredoxin + O2
1-tetracosanol + oxidized rubredoxin + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-