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(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
1,1-diethylcyclopropane + NADPH + H+ + O2
?
1,7-octadiene + NADH + H+ + O2
1,2-epoxy-7-octene + NAD+ + H2O
-
epoxidation of simple, aliphatic terminal olefins
-
-
?
1-hexadecene + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
1-octadecene + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
1-octene + reduced rubredoxin + O2
1,2-epoxyoctane + oxidized rubredoxin + H2O
2 1-octyne + 2 NADH + 2 H+ + 2 O2
1-octanoic acid + 7-octynoic acid + 2 NAD+ + 2 H2O
-
-
-
-
?
2,5-dimethylhexane + NADH + H+ + O2
?
-
-
-
-
?
5,8,11-eicosatrienoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
bicyclohexane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
i.e. bicyclo[3.1.0]hexane, no distinction between the 2- and 3-positions, reaction via formation of a substrate radical that persists in the active site
-
-
?
butane + NADPH + H+ + O2
1-butanol + NADP+ + H2O
cycloheptane + NAD(P)H + H+ + O2
cycloheptanol + NAD(P)+ + H2O
cyclohexane + NAD(P)H + H+ + O2
cyclohexanol + NAD(P)+ + H2O
cyclohexane + NADH + H+ + O2
cyclohexanol + NAD+ + H2O
-
-
-
-
?
cyclooctane + NAD(P)H + H+ + O2
cyclooctanol + NAD(P)+ + H2O
cyclopentane + NAD(P)H + H+ + O2
cyclopentanol + NAD(P)+ + H2O
-
very poor substrate
-
-
?
decane + reduced rubredoxin + O2
1-decanol + oxidized rubredoxin + H2O
-
-
-
-
?
decane + reduced rubredoxin + O2 + H+
1-decanol + oxidized rubredoxin + H2O
-
-
-
-
r
dicyclopropylketone + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
?
docosahexaenoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
-
?
dodecane + reduced rubredoxin + O2
1-dodecanol + oxidized rubredoxin + H2O
-
-
-
-
?
eicosapentaenoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
is less omega-hydroxylated than 5,8,11-eicosatrienoic acid and arachidonic acid
-
-
?
ethyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
heptadecane + reduced rubredoxin + O2
1-heptadecanol + oxidized rubredoxin + H2O
-
-
-
-
?
heptanoate + NADPH + H+ + O2
?
-
59% activity compared to octane
-
-
r
hexadecane + reduced rubredoxin + O2
1-hexadecanol + oxidized rubredoxin + H2O
-
-
-
-
?
hexane + reduced rubredoxin + O2
1-hexanol + oxidized rubredoxin + H2O
-
-
-
-
?
hexane + reduced rubredoxin + O2 + H+
1-hexanol + oxidized rubredoxin + H2O
-
-
-
-
r
hexanoate + NADPH + H+ + O2
?
-
25% activity compared to octane
-
-
r
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxydodecanoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lecithin + NADH + H+ + O2
?
-
-
-
-
?
methane + NADPH + H+ + O2
methanol + NADP+ + H2O
methane sulfonic acid + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + formaldehyde
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + methanol
-
-
-
?
methylcyclohexane + NADH + H+ + O2
?
-
-
-
-
?
methylphenylcyclopropane + reduced rubredoxin + O2
1-phenylbut-3-en-1-ol + oxidized rubredoxin + H2O
-
reaction via formation of a substrate radical that persists in the active site
-
-
?
monoolein + NADH + H+ + O2
18-hydroxyoctadec-9-enoic acid 2,3-dihydroxypropyl ester + NAD+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
n-butane + reduced rubredoxin + O2
1-butanol + oxidized rubredoxin + H2O
n-dodecane + 2 reduced rubredoxin + O2 + 2 H+
1-dodecanol + 2 oxidized rubredoxin + H2O
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
n-propane + reduced rubredoxin + O2
1-propanol + oxidized rubredoxin + H2O
nitromethane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
nonanoate + NADPH + H+ + O2
?
-
25% activity compared to octane
-
-
r
norcarane + NADPH + H+ + O2
?
norcarane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
i.e. bicyclo[4.1.0]heptane, oxidation preferentially occurs at the less sterically hindered 3-position, reaction via formation of a substrate radical that persists in the active site
-
-
?
octadecane + reduced rubredoxin + O2
1-octadecanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
pentadecane + reduced rubredoxin + O2
1-pentadecanol + oxidized rubredoxin + H2O
-
best substrate
-
-
?
pentane + reduced rubredoxin + O2
1-pentanol + oxidized rubredoxin + H2O
-
-
-
-
?
phosphatidylethanolamine + NADH + H+ + O2
?
-
-
-
-
?
phosphatidylserine + NADH + H+ + O2
?
-
-
-
-
?
propane + NADPH + H+ + O2
1-propanol + NADP+ + H2O
propane + NADPH + H+ + O2
propan-1-ol + NADP+ + H2O
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9 -
-
-
?
propane + NADPH + H+ + O2
propanol + NADP+ + H2O
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
?
prostaglandin A2 + NADPH + O2
?
-
-
-
-
?
prostaglandin E1 + NADPH + O2
?
-
-
-
-
?
spirooctane + NADPH + H+ + O2
?
stearic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
-
?
suberin + NADPH + H+ + O2
? + NADP+ + H2O
-
-
-
?
tert-amyl methyl ether + NAD(P)H + H+ + O2
tert-amyl-alcohol + NAD(P)+ + H2O + formaldehyde
tetracosane + reduced rubredoxin + O2
1-tetracosanol + oxidized rubredoxin + H2O
-
-
-
-
?
additional information
?
-
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
chain length C10-C16
-
-
?
1,1-diethylcyclopropane + NADPH + H+ + O2
?
-
-
-
-
?
1,1-diethylcyclopropane + NADPH + H+ + O2
?
-
-
-
-
?
1-octene + reduced rubredoxin + O2
1,2-epoxyoctane + oxidized rubredoxin + H2O
epoxidation reaction catalysed by AlkB
-
-
?
1-octene + reduced rubredoxin + O2
1,2-epoxyoctane + oxidized rubredoxin + H2O
epoxidation reaction catalysed by AlkB
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
product formation relaxes distal human pulmonary arteries
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
the rate of metabolism by CYPA11 P450 is 10-100fold less as compared to lauric acid
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
-
-
-
?
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
-
-
-
?
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
-
-
-
?
butane + NADPH + H+ + O2
1-butanol + NADP+ + H2O
-
-
-
-
?
butane + NADPH + H+ + O2
1-butanol + NADP+ + H2O
-
-
-
-
?
cycloheptane + NAD(P)H + H+ + O2
cycloheptanol + NAD(P)+ + H2O
-
-
-
-
?
cycloheptane + NAD(P)H + H+ + O2
cycloheptanol + NAD(P)+ + H2O
-
-
-
-
?
cyclohexane + NAD(P)H + H+ + O2
cyclohexanol + NAD(P)+ + H2O
-
-
-
-
?
cyclohexane + NAD(P)H + H+ + O2
cyclohexanol + NAD(P)+ + H2O
-
-
-
-
?
cyclooctane + NAD(P)H + H+ + O2
cyclooctanol + NAD(P)+ + H2O
-
poor substrate
-
-
?
cyclooctane + NAD(P)H + H+ + O2
cyclooctanol + NAD(P)+ + H2O
-
poor substrate
-
-
?
ethyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
-
-
-
-
?
ethyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for fatty acids than for alkanes
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
high affinity for short chain fatty acids
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for fatty acids than for alkanes
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
NADPH-P-450 reductase and omega-hydrolase are 1 protein
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
pig liver NADPH-P450 reductase and cytochrome b5 are part of the system
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
3D-structure analysis, substrate pocket determination
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
medium-chain fatty acids
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C12-C16, arachidonic acid and oleic acid
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
laurate and arachidonic acid
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C10-C19
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
NADPH-P450 reductase and cytochrome b5 are part of the enzyme system
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C6-C14
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C6-C11, maximal activity with heptanoate
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C12-C16, arachidonic acid and oleic acid
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
CYPA11 P450 efficiently and selectively omega-hydroxylates lauric acid
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
methane + NADPH + H+ + O2
methanol + NADP+ + H2O
-
-
-
-
?
methane + NADPH + H+ + O2
methanol + NADP+ + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for alkanes than for fatty acids
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for alkanes than for fatty acids
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
acts on C5-C13 alkanes, highest activity with n-hexane
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
acts on C5-C13 alkanes, highest activity with n-hexane
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C10-C16 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C10-C16 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
alkanes above C6
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
alkanes above C6
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
rubredoxin is electron carrier
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
chain length C6-C14
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
chain length C6-C16, maximal activity with n-octane
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
possible role in compensating low hydrocarbon concentrations
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
native strain oxidizes C6-C13 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C5-C12 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
possible role in compensating low hydrocarbon concentrations
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C5-C12 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
native strain oxidizes C6-C13 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
-
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
initial activation of alkanes
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
-
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
-
-
-
?
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
-
-
-
-
?
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
-
-
-
-
?
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
-
-
-
-
?
n-butane + reduced rubredoxin + O2
1-butanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-butane + reduced rubredoxin + O2
1-butanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-dodecane + 2 reduced rubredoxin + O2 + 2 H+
1-dodecanol + 2 oxidized rubredoxin + H2O
-
-
-
?
n-dodecane + 2 reduced rubredoxin + O2 + 2 H+
1-dodecanol + 2 oxidized rubredoxin + H2O
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
NADPH-cyt P-450-reductase
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
NADPH-cyt P-450-reductase
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
-
cytochrome P450 is electron carrier
-
-
?
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
-
cytochrome P450 is electron carrier
-
-
?
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
-
-
-
-
?
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-propane + reduced rubredoxin + O2
1-propanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-propane + reduced rubredoxin + O2
1-propanol + oxidized rubredoxin + H2O
-
-
-
-
?
norcarane + NADPH + H+ + O2
?
-
-
-
-
?
norcarane + NADPH + H+ + O2
?
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
CYPA11 P450 shows less selectivity in the metabolism of palmitic acid where both omega and omega-1 products are produced
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
propane + NADPH + H+ + O2
1-propanol + NADP+ + H2O
-
-
-
-
?
propane + NADPH + H+ + O2
1-propanol + NADP+ + H2O
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9 -
-
-
?
propane + NADPH + H+ + O2
propanol + NADP+ + H2O
-
-
-
-
?
propane + NADPH + H+ + O2
propanol + NADP+ + H2O
-
-
-
-
?
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
spirooctane + NADPH + H+ + O2
?
-
-
-
-
?
spirooctane + NADPH + H+ + O2
?
-
-
-
-
?
tert-amyl methyl ether + NAD(P)H + H+ + O2
tert-amyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
tert-amyl methyl ether + NAD(P)H + H+ + O2
tert-amyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C8 to C12
-
-
?
additional information
?
-
-
AbAlkB can catalyze the hydroxylation of a large number of aromatic compounds and linear and cyclic alkanes. It does not catalyze the hydroxylation of alkanes with a chain length longer than 15 carbons, nor does it hydroxylate sterically hindered C-H bonds. GC-MS product analysis, overview. AbAlkB hydroxylates the terminal methyl group of medium chain alkanes, where octane is apparently close to the optimal chain length
-
-
?
additional information
?
-
-
20-hydroxyeicosatetraenoic acid modulates renal transport activities
-
-
?
additional information
?
-
-
CYP4A prefers to metabolize medium chain fatty acids (C10-C16)
-
-
?
additional information
?
-
-
CYP4A prefers to metabolize medium chain fatty acids (C10C16)
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C10 to C16
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C10 to C16
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C12 to C16
-
-
?
additional information
?
-
-
substrates of one isoform are alkanes of chain length C12 to C16, the second isoform hydroxylates octadecan or eicosan
-
-
?
additional information
?
-
-
the enzyme also catalyzes the oxygenative O-demethylation of ethers, the sulfoxidation of methyl sulfides and the stereoselective epoxidation of terminal olefins
-
-
?
additional information
?
-
-
physiological role of enzyme complex is to initiate the monoterminal oxidation of alkane chains
-
-
?
additional information
?
-
-
does not catalyze the hydroxylation of 1,1-dimethylcyclopropane or 1,1,2,2-tetramethylcyclopropane
-
-
?
additional information
?
-
-
AlkB, a nonheme diiron monooxygenase, performs regioselectibe hydroxylation of gem-difluorinated octanes, synthesis of 2,2-, 3,3- and 4,4-difluorooctan-1-ols from 1-octanal and 2-, 3-, 4-octanones, NMR and GC/MS product analysis, overview. Reactions of AlkB with 3,3- and 4,4-difluorooctanes and 1,1,1-trifluoroctane, synthesis of 2,2-, 3,3- 4,4-difluorooctan-1-ols, and of 8,8-, 7,7-, 6,6- and 5,5-difluorooctan-1-ols, overview
-
-
?
additional information
?
-
-
does not catalyze the hydroxylation of 1,1-dimethylcyclopropane or 1,1,2,2-tetramethylcyclopropane
-
-
?
additional information
?
-
-
AlkB, a nonheme diiron monooxygenase, performs regioselectibe hydroxylation of gem-difluorinated octanes, synthesis of 2,2-, 3,3- and 4,4-difluorooctan-1-ols from 1-octanal and 2-, 3-, 4-octanones, NMR and GC/MS product analysis, overview. Reactions of AlkB with 3,3- and 4,4-difluorooctanes and 1,1,1-trifluoroctane, synthesis of 2,2-, 3,3- 4,4-difluorooctan-1-ols, and of 8,8-, 7,7-, 6,6- and 5,5-difluorooctan-1-ols, overview
-
-
?
additional information
?
-
-
substrate specificity of the alkane hydroxylase large subunit, overview. Poor activity with 1-tetradecanol, no activity with octacosane, benzene, sodium benzoate, toluene, catechol, biphenyl, 1-hexadecanol, 1-stearyl alcohol, isooctane, pristine, and squalane
-
-
?
additional information
?
-
dodecane strongly binds to Cyp153D17 with similar Kd values as C10-C12 fatty acids
-
-
?