1.14.15.4: steroid 11beta-monooxygenase

This is an abbreviated version!
For detailed information about steroid 11beta-monooxygenase, go to the full flat file.

Reaction

Synonyms

11
-hydroxylase, 11 beta-hydroxylase, 11-beta hydroxylase, 11-beta-hydroxylase, 11-hydroxylase, 11beta hydroxylase, 11beta-hydroxylase, ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, C450XIB2, CYP11B1, CYP11B2, cyp11beta, CYPXIB, CYPXIB1, CYPXIB2, CYPXIB3, cytochrome 11beta-hydroxylase, cytochrome P-45011-beta, cytochrome P450 11B1, cytochrome P450 11B2, cytochrome P450 11beta-hydroxylase, cytochrome P45011beta, cytochrome P45011beta-hydroxylase, EC 1.14.1.6, EC 1.99.1.7, P-450(11 beta,aldo), P-450Aldo, P-450c11, P-450C18, P-450XIB1, P450 11beta-hydroxylase, P450(11 beta)-DS, P45011beta, P450C11, Steroid 11-beta-hydroxylase, steroid 11-hydroxylase, steroid 11beta-hydroxylase, steroid 11beta-monooxygenase, steroid 11beta/18-hydroxylase, Steroid 18-hydroxylase, steroid-11beta-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.15.4 steroid 11beta-monooxygenase

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Results	in table
14	Activating Compound
138	AA Sequence
9	Application
1	CAS Registry Number
36	Cloned(Commentary)
53	Cofactor
1	Crystallization (Commentary)
4812	Disease/ Diagnostics
2	Expression
16	General Information
15	General Stability
213	IC50 Value
224	Inhibitors
4	Ki Value [mM]
27	KM Value [mM]
39	Localization
3	Metals/Ions
22	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
83	Organism
7	Pathway
60	PDB ID
26	pH Optimum
1	pH Range
35	Protein Variants
21	Purification (Commentary)
15	Reaction
4	Reaction Type
80	Reference
104	Source Tissue
31	Specific Activity [micromol/min/mg]
20	Storage Stability
138	Substrates and Products (Substrate)
20	Subunits
139	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
11	Turnover Number [1/s]

General Information

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General Information on EC 1.14.15.4 - steroid 11beta-monooxygenase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Homo sapiens

P15538, P19099

although the active site pocket is lined by identical residues between CYP11B isoforms, most of the divergent residues that confer additional 18-oxidase activity of aldosterone synthase are located in the I-helix, vicinity of the O2 activation path and loops around the H-helix, affecting an egress channel closure required for retaining intermediates in the active site

725981

malfunction

2 entries

metabolism

4 entries

physiological function

4 entries

additional information

8 entries

malfunction

Homo sapiens

-

familial hyperaldosteronism type I is caused by the unequal recombination between the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes, resulting in the generation of a CYP11B1/B2 chimeric gene and abnormal adrenal aldosterone production, which leads to severe hypertension and an elevated frequency of stroke at a young age

726468

malfunction

Homo sapiens

-

overproduction of aldosterone in the adrenal gland can lead to hypertension, a major cause of heart disease and stroke

726012

metabolism

Homo sapiens

-

aldosterone synthase, CYP11B2, is the key enzyme of mineralocorticoid biosynthesis and its malfunction is involved in hyperaldosteronism, congestive heart failure, and myocardial fibrosis

712715

metabolism

Homo sapiens

-

CYP11B1 is a key enzyme in the biosynthesis of cortisol. CYP11B2 catalyzes the last three steps of aldosterone biosynthesis

711420

metabolism

Homo sapiens

P19099

human aldosterone synthase is responsible for the biosynthesis of aldosterone from 11-deoxycorticosterone in a sequential three-step reaction with two intermediates, corticosterone and 18-hydroxycorticosterone

725828

metabolism

Homo sapiens

-

very-low-density lipoprotein mediates transcriptional upregulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways, e.g. partially through scavenger receptor class B type I. Aldosterone, apart from its role in fluid and electrolyte homeostasis, is implicated in insulin resistance and myocardial fibrosis. Impact of VLDL as a potential risk factor for aldosterone-mediated cardiovascular injury in diabetes mellitus, intracellular mechanism, overview

724701

physiological function

Homo sapiens

-

steroid 11beta-hydroxylase converts 11-deoxycortisol and 11-deoxycorticosterone to cortisol and corticosterone, respectively

712572

physiological function

Homo sapiens

-

aldosterone synthase regulates blood volume by synthesizing the mineralocorticoid aldosterone. Subcellular mechanisms of enzyme localization relate to production of aldosterone and reveal a rapid, promoter-independent regulation of aldosterone production

726012

physiological function

Homo sapiens

P15538, P19099

aldosterone synthase, CYP11B2, is the sole enzyme responsible for the production of aldosterone in humans

725981

physiological function

Homo sapiens

-

progesterone might regulate the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 enzymatic activities and contribute to the decay of aldosterone synthase activity in CYP11B1/B2 chimeric gene-positive patients. This regulatory mechanism of progesterone action might be involved in protecting pregnant women with FH-1 against hypertension

726468

additional information

Homo sapiens

-

steroid 11beta-hydroxylase, CYP11B1, deficiency, i.e. 11OHD, is the second most common form of congenital adrenal hyperplasia. Cases of nonclassic 11OHD are rare compared with the incidence of nonclassic 21-hydroxylase deficiency, genotypes and phenotypes, overview

712572

additional information

Homo sapiens

P15538

a hydrophobic cavity with specific features is associated with corticosteroid recognition, substrate binding mode, overview

725981

additional information

Homo sapiens

P19099

a hydrophobic cavity with specific features is associated with corticosteroid recognition, substrate binding mode, overview

725981

additional information

Homo sapiens

-

a hydrophobic cavity with specific features is associated with corticosteroid recognition, substrate binding mode, overview

725981

additional information

Homo sapiens

P19099

homology modeling and molecular docking of CYP11B2, overview

725828

additional information

Homo sapiens

-

homology modeling and molecular docking of CYP11B2, overview

725828

additional information

Homo sapiens

-

molecular modelling of CYP11B1 and CYP11B1/B2 chimeric proteins and steroids docking, overview

726468

additional information

Homo sapiens

-

N-terminal 26 amino acids of the enzyme target cargo protein DHFR to the mitochondria

726012